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High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum.
Liu Z, Yokoyama NN, Blair CA, Li X, Avizonis D, Wu XR, Uchio E, Youssef R, McClelland M, Pollak M, Zi X. Liu Z, et al. Among authors: avizonis d. Mol Cancer Ther. 2016 Mar;15(3):430-8. doi: 10.1158/1535-7163.MCT-15-0714-T. Epub 2016 Feb 26. Mol Cancer Ther. 2016. PMID: 26921394 Free PMC article.
Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.
Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I. Hulea L, et al. Among authors: avizonis d. Cell Metab. 2018 Dec 4;28(6):817-832.e8. doi: 10.1016/j.cmet.2018.09.001. Epub 2018 Sep 20. Cell Metab. 2018. PMID: 30244971 Free PMC article.
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.
Xu G, van Bruggen R, Gualtieri CO, Moradin N, Fois A, Vallerand D, De Sa Tavares Russo M, Bassenden A, Lu W, Tam M, Lesage S, Girouard H, Avizonis DZ, Deblois G, Prchal JT, Stevenson M, Berghuis A, Muir T, Rabinowitz J, Vidal SM, Fodil N, Gros P. Xu G, et al. Among authors: avizonis dz. Cell Rep. 2020 Sep 22;32(12):108170. doi: 10.1016/j.celrep.2020.108170. Cell Rep. 2020. PMID: 32966787 Free article.
STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer.
Totten SP, Im YK, Cepeda Cañedo E, Najyb O, Nguyen A, Hébert S, Ahn R, Lewis K, Lebeau B, La Selva R, Sabourin V, Martínez C, Savage P, Kuasne H, Avizonis D, Santos Martínez N, Chabot C, Aguilar-Mahecha A, Goulet ML, Dankner M, Witcher M, Petrecca K, Basik M, Pollak M, Topisirovic I, Lin R, Siegel PM, Kleinman CL, Park M, St-Pierre J, Ursini-Siegel J. Totten SP, et al. Among authors: avizonis d. Nat Commun. 2021 Jun 3;12(1):3299. doi: 10.1038/s41467-021-23396-2. Nat Commun. 2021. PMID: 34083537 Free PMC article.
Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss.
Zhu X, Fu Z, Chen SY, Ong D, Aceto G, Ho R, Steinberger J, Monast A, Pilon V, Li E, Ta M, Ching K, Adams BN, Negri GL, Choiniere L, Fu L, Pavlakis K, Pirrotte P, Avizonis DZ, Trent J, Weissman BE, Klein Geltink RI, Morin GB, Park M, Huntsman DG, Foulkes WD, Wang Y, Huang S. Zhu X, et al. Among authors: avizonis dz. Nat Commun. 2023 May 20;14(1):2894. doi: 10.1038/s41467-023-38594-3. Nat Commun. 2023. PMID: 37210563 Free PMC article.
MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors.
Kim H, Lebeau B, Papadopoli D, Jovanovic P, Russo M, Avizonis D, Morita M, Afzali F, Ursini-Siegel J, Postovit LM, Witcher M, Topisirovic I. Kim H, et al. Among authors: avizonis d. iScience. 2024 Feb 12;27(3):109188. doi: 10.1016/j.isci.2024.109188. eCollection 2024 Mar 15. iScience. 2024. PMID: 38433910 Free PMC article.
Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis.
Biondini M, Lehuédé C, Tabariès S, Annis MG, Pacis A, Ma EH, Tam C, Hsu BE, Audet-Delage Y, Abu-Thuraia A, Girondel C, Sabourin V, Totten SP, de Sá Tavares Russo M, Bridon G, Avizonis D, Guiot MC, St-Pierre J, Ursini-Siegel J, Jones R, Siegel PM. Biondini M, et al. Among authors: avizonis d. Redox Biol. 2024 Sep;75:103276. doi: 10.1016/j.redox.2024.103276. Epub 2024 Jul 20. Redox Biol. 2024. PMID: 39053265 Free PMC article.
51 results