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Identifying drug targets in tissues and whole blood with thermal-shift profiling.
Perrin J, Werner T, Kurzawa N, Rutkowska A, Childs DD, Kalxdorf M, Poeckel D, Stonehouse E, Strohmer K, Heller B, Thomson DW, Krause J, Becher I, Eberl HC, Vappiani J, Sevin DC, Rau CE, Franken H, Huber W, Faelth-Savitski M, Savitski MM, Bantscheff M, Bergamini G. Perrin J, et al. Among authors: sevin dc. Nat Biotechnol. 2020 Mar;38(3):303-308. doi: 10.1038/s41587-019-0388-4. Epub 2020 Jan 20. Nat Biotechnol. 2020. PMID: 31959954
An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices.
Khan MM, Poeckel D, Halavatyi A, Zukowska-Kasprzyk J, Stein F, Vappiani J, Sevin DC, Tischer C, Zinn N, Eley JD, Gudmann NS, Muley T, Winter H, Fisher AJ, Nanthakumar CB, Bergamini G, Pepperkok R. Khan MM, et al. Among authors: sevin dc. Eur Respir J. 2021 Jul 1;58(1):2000221. doi: 10.1183/13993003.00221-2020. Print 2021 Jul. Eur Respir J. 2021. PMID: 33361096 Free PMC article.
New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids.
Rodrigues D, de Souza T, Coyle L, Di Piazza M, Herpers B, Ferreira S, Zhang M, Vappiani J, Sévin DC, Gabor A, Lynch A, Chung SW, Saez-Rodriguez J, Jennen DGJ, Kleinjans JCS, de Kok TM. Rodrigues D, et al. Among authors: sevin dc. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20. Arch Toxicol. 2021. PMID: 34151400 Free PMC article.
Bioaccumulation of therapeutic drugs by human gut bacteria.
Klünemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, Vappiani J, Simon B, Scott TA, Kafkia E, Konstantinidis D, Zirngibl K, Mastrorilli E, Banzhaf M, Mackmull MT, Hövelmann F, Nesme L, Brochado AR, Maier L, Bock T, Periwal V, Kumar M, Kim Y, Tramontano M, Schultz C, Beck M, Hennig J, Zimmermann M, Sévin DC, Cabreiro F, Savitski MM, Bork P, Typas A, Patil KR. Klünemann M, et al. Among authors: sevin dc. Nature. 2021 Sep;597(7877):533-538. doi: 10.1038/s41586-021-03891-8. Epub 2021 Sep 8. Nature. 2021. PMID: 34497420 Free PMC article.
Metabolic memory underlying minimal residual disease in breast cancer.
Radic Shechter K, Kafkia E, Zirngibl K, Gawrzak S, Alladin A, Machado D, Lüchtenborg C, Sévin DC, Brügger B, Patil KR, Jechlinger M. Radic Shechter K, et al. Among authors: sevin dc. Mol Syst Biol. 2021 Oct;17(10):e10141. doi: 10.15252/msb.202010141. Mol Syst Biol. 2021. PMID: 34694069 Free PMC article.
29 results