Loss of p53 compensates osteopenia in murine Mysm1 deficiency.
Haffner-Luntzer M, Kovtun A, Fischer V, Prystaz K, Hainzl A, Kroeger CM, Krikki I, Brinker TJ, Ignatius A, Gatzka M.
Haffner-Luntzer M, et al. Among authors: fischer v.
FASEB J. 2018 Apr;32(4):1957-1968. doi: 10.1096/fj.201700871R. Epub 2018 Jan 5.
FASEB J. 2018.
PMID: 29203593
In summary, our results demonstrate novel roles for Mysm1 in osteoblast differentiation and osteoclast formation, resulting in osteopenia in Mysm1-deficient mice that could be abrogated by the loss of p53 from increased osteogenic differentiation of Mysm1(-/-)p53(-/-) MSCs.-Haffn …
In summary, our results demonstrate novel roles for Mysm1 in osteoblast differentiation and osteoclast formation, resulting in osteopenia in …