McIntosh T - Search Results

1

Best practices for optimization and validation of flow cytometry-based receptor occupancy assays.

Hilt E, Sun YS, McCloskey TW, Eck S, McIntosh T, Grugan KD, Lanham DF, Standifer N, Green C, Litwin V, Stewart JJ. Hilt E, et al. Among authors: mcintosh t. Cytometry B Clin Cytom. 2021 Jan;100(1):63-71. doi: 10.1002/cyto.b.21970. Epub 2020 Dec 1. Cytometry B Clin Cytom. 2021. PMID: 33259706 Free article.

2

Utility of free and total target measurements as target engagement and efficacy biomarkers in biotherapeutic development--opportunities and challenges.

Zheng S, McIntosh T, Wang W. Zheng S, et al. Among authors: mcintosh t. J Clin Pharmacol. 2015 Mar;55 Suppl 3:S75-84. doi: 10.1002/jcph.357. J Clin Pharmacol. 2015. PMID: 25707966 Review.

3

Mechanistic pharmacokinetic/target engagement/pharmacodynamic (PK/TE/PD) modeling in deciphering interplay between a monoclonal antibody and its soluble target in cynomolgus monkeys.

Wang W, Wang X, Doddareddy R, Fink D, McIntosh T, Davis HM, Zhou H. Wang W, et al. Among authors: mcintosh t. AAPS J. 2014 Jan;16(1):129-39. doi: 10.1208/s12248-013-9545-8. Epub 2013 Nov 28. AAPS J. 2014. PMID: 24287601 Free PMC article.

4

Development and Translational Application of a Minimal Physiologically Based Pharmacokinetic Model for a Monoclonal Antibody against Interleukin 23 (IL-23) in IL-23-Induced Psoriasis-Like Mice.

Chen X, Jiang X, Doddareddy R, Geist B, McIntosh T, Jusko WJ, Zhou H, Wang W. Chen X, et al. Among authors: mcintosh t. J Pharmacol Exp Ther. 2018 Apr;365(1):140-155. doi: 10.1124/jpet.117.244855. Epub 2018 Feb 2. J Pharmacol Exp Ther. 2018. PMID: 29420255

5

A novel approach to evaluate the pharmacokinetic biocomparability of a monoclonal antibody derived from two different cell lines using simultaneous crossover design.

Han C, McIntosh TS, Geist BJ, Jiao T, Puchalski TA, Goldberg KM, Yang TY, Pendley CE, Zhou H, Davis HM. Han C, et al. Among authors: mcintosh ts. AAPS J. 2014 Jan;16(1):125-8. doi: 10.1208/s12248-013-9547-6. Epub 2013 Nov 27. AAPS J. 2014. PMID: 24281691 Free PMC article.

6

Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model.

Wang W, McIntosh TS, Jiang X, Doddareddy R, Dell EC, Zhou H. Wang W, et al. Pharm Res. 2016 Apr;33(4):1040-9. doi: 10.1007/s11095-015-1850-8. Epub 2015 Dec 30. Pharm Res. 2016. PMID: 26718954

7

A novel approach for the simultaneous quantification of a therapeutic monoclonal antibody in serum produced from two distinct host cell lines.

Geist BJ, Davis D, McIntosh T, Yang TY, Goldberg K, Han C, Pendley C, Davis HM. Geist BJ, et al. Among authors: mcintosh t. MAbs. 2013 Jan-Feb;5(1):150-61. doi: 10.4161/mabs.22773. Epub 2012 Nov 26. MAbs. 2013. PMID: 23182963 Free PMC article.

8

Utilizing pharmacokinetics/pharmacodynamics modeling to simultaneously examine free CCL2, total CCL2 and carlumab (CNTO 888) concentration time data.

Fetterly GJ, Aras U, Meholick PD, Takimoto C, Seetharam S, McIntosh T, de Bono JS, Sandhu SK, Tolcher A, Davis HM, Zhou H, Puchalski TA. Fetterly GJ, et al. Among authors: mcintosh t. J Clin Pharmacol. 2013 Oct;53(10):1020-7. doi: 10.1002/jcph.140. Epub 2013 Jul 23. J Clin Pharmacol. 2013. PMID: 23878055 Clinical Trial.

9

A liquid chromatography-mass spectrometry method to measure stable isotopic tracer enrichments of glycerol and glucose in human serum.

McIntosh TS, Davis HM, Matthews DE. McIntosh TS, et al. Anal Biochem. 2002 Jan 15;300(2):163-9. doi: 10.1006/abio.2001.5455. Anal Biochem. 2002. PMID: 11779107

10

Development of different analysis platforms with LC-MS for pharmacokinetic studies of protein drugs.

Lu Q, Zheng X, McIntosh T, Davis H, Nemeth JF, Pendley C, Wu SL, Hancock WS. Lu Q, et al. Among authors: mcintosh t. Anal Chem. 2009 Nov 1;81(21):8715-23. doi: 10.1021/ac901991x. Anal Chem. 2009. PMID: 19788250 Free PMC article.

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