Kikelj D - Search Results

1

Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors.

Skok Ž, Barančoková M, Benek O, Cruz CD, Tammela P, Tomašič T, Zidar N, Mašič LP, Zega A, Stevenson CEM, Mundy JEA, Lawson DM, Maxwell A, Kikelj D, Ilaš J. Skok Ž, et al. Among authors: kikelj d. ACS Med Chem Lett. 2020 Oct 15;11(12):2433-2440. doi: 10.1021/acsmedchemlett.0c00416. eCollection 2020 Dec 10. ACS Med Chem Lett. 2020. PMID: 33329764 Free PMC article.

2

Design and structure-activity relationship of thrombin inhibitors with an azaphenylalanine scaffold: potency and selectivity enhancements via P2 optimization.

Zega A, Mlinsek G, Sepic P, Golic Grdadolnik S, Solmajer T, Tschopp TB, Steiner B, Kikelj D, Urleb U. Zega A, et al. Among authors: kikelj d. Bioorg Med Chem. 2001 Oct;9(10):2745-56. doi: 10.1016/s0968-0896(01)00202-4. Bioorg Med Chem. 2001. PMID: 11557360

3

Novel thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics: optimization via modification of P1 and P3 moieties.

Kranjc A, Peterlin-Masic L, Ilas J, Prezelj A, Stegnar M, Kikelj D. Kranjc A, et al. Among authors: kikelj d. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3251-6. doi: 10.1016/j.bmcl.2004.03.085. Bioorg Med Chem Lett. 2004. PMID: 15149685

4

Toward a novel class of antithrombotic compounds with dual function. Discovery of 1,4-benzoxazin-3(4H)-one derivatives possessing thrombin inhibitory and fibrinogen receptor antagonistic activities.

Stefanic Anderluh P, Anderluh M, Ilas J, Mravljak J, Sollner Dolenc M, Stegnar M, Kikelj D. Stefanic Anderluh P, et al. Among authors: kikelj d. J Med Chem. 2005 May 5;48(9):3110-3. doi: 10.1021/jm048984g. J Med Chem. 2005. PMID: 15857114

5

Novel pyrazinone and pyridinone thrombin inhibitors incorporating weakly basic heterobicyclic P(1)-arginine mimetics.

Kranjc A, Masic LP, Reven S, Mikic K, Prezelj A, Stegnar M, Kikelj D. Kranjc A, et al. Among authors: kikelj d. Eur J Med Chem. 2005 Aug;40(8):782-91. doi: 10.1016/j.ejmech.2005.03.007. Eur J Med Chem. 2005. PMID: 15890436

6

Peptides and pseudopeptides incorporating D-Phe-Pro-Arg and Arg-Gly-Asp lead sequences as potential antithrombotic agents.

Ilas J, Hudecz F, Süli-Vargha H, Kikelj D. Ilas J, et al. Among authors: kikelj d. J Pept Sci. 2008 Aug;14(8):946-53. doi: 10.1002/psc.1030. J Pept Sci. 2008. PMID: 18383437

7

Novel potent and selective thrombin inhibitors based on a central 1,4-benzoxazin-3(4H)-one scaffold.

Ilas J, Tomasić T, Kikelj D. Ilas J, et al. Among authors: kikelj d. J Med Chem. 2008 May 8;51(9):2863-7. doi: 10.1021/jm701622y. Epub 2008 Apr 16. J Med Chem. 2008. PMID: 18412326

8

3,4-Dihydro-2H-1,4-benzoxazine derivatives combining thrombin inhibitory and glycoprotein IIb/IIIa receptor antagonistic activity as a novel class of antithrombotic compounds with dual function.

Ilas J, Jakopin Z, Borstnar T, Stegnar M, Kikelj D. Ilas J, et al. Among authors: kikelj d. J Med Chem. 2008 Sep 25;51(18):5617-29. doi: 10.1021/jm8003448. Epub 2008 Aug 27. J Med Chem. 2008. PMID: 18729445

9

Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase.

Tomasić T, Zidar N, Rupnik V, Kovac A, Blanot D, Gobec S, Kikelj D, Masic LP. Tomasić T, et al. Among authors: kikelj d. Bioorg Med Chem Lett. 2009 Jan 1;19(1):153-7. doi: 10.1016/j.bmcl.2008.10.129. Epub 2008 Nov 5. Bioorg Med Chem Lett. 2009. PMID: 19014883

10

Azaphenylalanine-based serine protease inhibitors induce caspase-mediated apoptosis.

Celhar T, Batista Napotnik T, Obreza A, Zega A, Anderluh PS, Kikelj D, Mlinaric-Rascan I. Celhar T, et al. Among authors: kikelj d. Eur J Pharmacol. 2009 Jan 5;602(1):15-22. doi: 10.1016/j.ejphar.2008.11.008. Epub 2008 Nov 12. Eur J Pharmacol. 2009. PMID: 19032950

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