Lum L - Search Results

1

Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.

Ryan K, Bolaňos B, Smith M, Palde PB, Cuenca PD, VanArsdale TL, Niessen S, Zhang L, Behenna D, Ornelas MA, Tran KT, Kaiser S, Lum L, Stewart A, Gajiwala KS. Ryan K, et al. Among authors: lum l. J Biol Chem. 2021 Jan-Jun;296:100251. doi: 10.1074/jbc.RA120.016573. Epub 2021 Jan 9. J Biol Chem. 2021. PMID: 33361107 Free PMC article.

2

[No title available]

[No authors listed] [No authors listed] PMID: 33428942

3

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.

Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L. Dodge ME, et al. Among authors: lum l. J Biol Chem. 2012 Jun 29;287(27):23246-54. doi: 10.1074/jbc.M112.372029. Epub 2012 May 15. J Biol Chem. 2012. PMID: 22593577 Free PMC article.

4

Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN).

Tuladhar R, Yarravarapu N, Ma Y, Zhang C, Herbert J, Kim J, Chen C, Lum L. Tuladhar R, et al. Among authors: lum l. J Biol Chem. 2019 Apr 19;294(16):6273-6282. doi: 10.1074/jbc.RA118.007268. Epub 2019 Feb 8. J Biol Chem. 2019. PMID: 30737280 Free PMC article.

5

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.

Koirala S, Klein J, Zheng Y, Glenn NO, Eisemann T, Fon Tacer K, Miller DJ, Kulak O, Lu M, Finkelstein DB, Neale G, Tillman H, Vogel P, Strand DW, Lum L, Brautigam CA, Pascal JM, Clements WK, Potts PR. Koirala S, et al. Among authors: lum l. Cell Rep. 2020 Jul 21;32(3):107922. doi: 10.1016/j.celrep.2020.107922. Cell Rep. 2020. PMID: 32698014 Free article.

6

Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine.

Lum L, Chen C. Lum L, et al. Curr Med Chem. 2015;22(35):4091-103. doi: 10.2174/0929867322666150827094015. Curr Med Chem. 2015. PMID: 26310918 Free PMC article. Review.

7

A synthetic combinatorial approach to disabling deviant Hedgehog signaling.

Fan CW, Yarravarapu N, Shi H, Kulak O, Kim J, Chen C, Lum L. Fan CW, et al. Among authors: lum l. Sci Rep. 2018 Jan 18;8(1):1133. doi: 10.1038/s41598-018-19408-9. Sci Rep. 2018. PMID: 29348431 Free PMC article.

8

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).

Weskamp G, Schlöndorff J, Lum L, Becherer JD, Kim TW, Saftig P, Hartmann D, Murphy G, Blobel CP. Weskamp G, et al. Among authors: lum l. J Biol Chem. 2004 Feb 6;279(6):4241-9. doi: 10.1074/jbc.M307974200. Epub 2003 Nov 24. J Biol Chem. 2004. PMID: 14638693 Free article.

9

Deconstructing the hedgehog pathway in development and disease.

Jacob L, Lum L. Jacob L, et al. Among authors: lum l. Science. 2007 Oct 5;318(5847):66-8. doi: 10.1126/science.1147314. Science. 2007. PMID: 17916724 Free PMC article.

10

Hedgehog signaling pathway.

Jacob L, Lum L. Jacob L, et al. Among authors: lum l. Sci STKE. 2007 Oct 9;2007(407):cm6. doi: 10.1126/stke.4072007cm6. Sci STKE. 2007. PMID: 17925577 Review.

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