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New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.
Durcik M, Nyerges Á, Skok Ž, Skledar DG, Trontelj J, Zidar N, Ilaš J, Zega A, Cruz CD, Tammela P, Welin M, Kimbung YR, Focht D, Benek O, Révész T, Draskovits G, Szili PÉ, Daruka L, Pál C, Kikelj D, Mašič LP, Tomašič T. Durcik M, et al. Among authors: kimbung yr. Eur J Med Chem. 2021 Mar 5;213:113200. doi: 10.1016/j.ejmech.2021.113200. Epub 2021 Jan 22. Eur J Med Chem. 2021. PMID: 33524686
The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Maurer MF, Lewis KE, Kuijper JL, Ardourel D, Gudgeon CJ, Chandrasekaran S, Mudri SL, Kleist KN, Navas C, Wolfson MF, Rixon MW, Swanson R, Dillon SR, Levin SD, Kimbung YR, Akutsu M, Logan DT, Walse B, Swiderek KM, Peng SL. Maurer MF, et al. Among authors: kimbung yr. Nat Commun. 2022 Apr 4;13(1):1790. doi: 10.1038/s41467-022-29286-5. Nat Commun. 2022. PMID: 35379805 Free PMC article.