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MOTS-c reduces myostatin and muscle atrophy signaling.
Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, Zempo H, Fuku N, Maeda S, Oliveira PJ, Cohen P, Kim SJ. Kumagai H, et al. Among authors: huang a. Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E680-E690. doi: 10.1152/ajpendo.00275.2020. Epub 2021 Feb 8. Am J Physiol Endocrinol Metab. 2021. PMID: 33554779 Free PMC article.
A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease.
Kim SJ, Miller B, Hartel NG, Ramirez R 2nd, Braniff RG, Leelaprachakul N, Huang A, Wang Y, Arpawong TE, Crimmins EM, Wang P, Sun X, Liu C, Levy D, Yen K, Petzinger GM, Graham NA, Jakowec MW, Cohen P. Kim SJ, et al. Among authors: huang a. Mol Psychiatry. 2024 Feb;29(2):505-517. doi: 10.1038/s41380-023-02344-0. Epub 2024 Jan 3. Mol Psychiatry. 2024. PMID: 38167865 Free PMC article.
Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease.
Matthews I, Birnbaum A, Gromova A, Huang AW, Liu K, Liu EA, Coutinho K, McGraw M, Patterson DC, Banks MT, Nobles AC, Nguyen N, Merrihew GE, Wang L, Baeuerle E, Fernandez E, Musi N, MacCoss MJ, Miranda HC, La Spada AR, Cortes CJ. Matthews I, et al. Among authors: huang aw. Cell Rep. 2023 Nov 28;42(11):113436. doi: 10.1016/j.celrep.2023.113436. Epub 2023 Nov 11. Cell Rep. 2023. PMID: 37952157 Free PMC article.
Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways.
Feng S, Marhon SA, Sokolowski DJ, D'Costa A, Soares F, Mehdipour P, Ishak C, Loo Yau H, Ettayebi I, Patel PS, Chen R, Liu J, Zuzarte PC, Ho KC, Ho B, Ning S, Huang A, Arrowsmith CH, Wilson MD, Simpson JT, De Carvalho DD. Feng S, et al. Among authors: huang a. Nat Commun. 2024 Oct 29;15(1):9321. doi: 10.1038/s41467-024-53515-8. Nat Commun. 2024. PMID: 39472584
5,794 results