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MOTS-c reduces myostatin and muscle atrophy signaling.
Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, Zempo H, Fuku N, Maeda S, Oliveira PJ, Cohen P, Kim SJ. Kumagai H, et al. Among authors: wan j. Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E680-E690. doi: 10.1152/ajpendo.00275.2020. Epub 2021 Feb 8. Am J Physiol Endocrinol Metab. 2021. PMID: 33554779 Free PMC article.
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.
Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. Levine ME, et al. Among authors: wan j. Cell Metab. 2014 Mar 4;19(3):407-17. doi: 10.1016/j.cmet.2014.02.006. Cell Metab. 2014. PMID: 24606898 Free PMC article.
IGF-I regulates the age-dependent signaling peptide humanin.
Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. Lee C, et al. Among authors: wan j. Aging Cell. 2014 Oct;13(5):958-61. doi: 10.1111/acel.12243. Epub 2014 Jul 18. Aging Cell. 2014. PMID: 25040290 Free PMC article.
6,467 results