Graham TJ - Search Results

1

PARP Targeted Alpha-Particle Therapy Enhances Response to PD-1 Immune-Checkpoint Blockade in a Syngeneic Mouse Model of Glioblastoma.

Dabagian H, Taghvaee T, Martorano P, Martinez D, Samanta M, Watkins CM, Chai R, Mansfield A, Graham TJ, Maris JM, Pryma DA, Mach RH, Makvandi M. Dabagian H, et al. Among authors: graham tj. ACS Pharmacol Transl Sci. 2021 Jan 26;4(1):344-351. doi: 10.1021/acsptsci.0c00206. eCollection 2021 Feb 12. ACS Pharmacol Transl Sci. 2021. PMID: 33615184 Free PMC article.

2

Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation.

Hou C, Hsieh CJ, Li S, Lee H, Graham TJ, Xu K, Weng CC, Doot RK, Chu W, Chakraborty SK, Dugan LL, Mintun MA, Mach RH. Hou C, et al. Among authors: graham tj. ACS Chem Neurosci. 2018 Mar 21;9(3):578-586. doi: 10.1021/acschemneuro.7b00385. Epub 2017 Dec 3. ACS Chem Neurosci. 2018. PMID: 29099578 Free PMC article.

3

Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules.

Hsieh CJ, Ferrie JJ, Xu K, Lee I, Graham TJA, Tu Z, Yu J, Dhavale D, Kotzbauer P, Petersson EJ, Mach RH. Hsieh CJ, et al. ACS Chem Neurosci. 2018 Nov 21;9(11):2521-2527. doi: 10.1021/acschemneuro.8b00177. Epub 2018 May 16. ACS Chem Neurosci. 2018. PMID: 29750499 Free PMC article.

4

Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro.

Hsieh CJ, Xu K, Lee I, Graham TJA, Tu Z, Dhavale D, Kotzbauer P, Mach RH. Hsieh CJ, et al. ACS Omega. 2018 Apr 30;3(4):4486-4493. doi: 10.1021/acsomega.7b01897. Epub 2018 Apr 24. ACS Omega. 2018. PMID: 30221226 Free PMC article.

5

Synthesis and characterization of high affinity fluorogenic α-synuclein probes.

Lengyel-Zhand Z, Ferrie JJ, Janssen B, Hsieh CJ, Graham T, Xu KY, Haney CM, Lee VM, Trojanowski JQ, Petersson EJ, Mach RH. Lengyel-Zhand Z, et al. Chem Commun (Camb). 2020 Mar 24;56(24):3567-3570. doi: 10.1039/c9cc09849f. Chem Commun (Camb). 2020. PMID: 32104795 Free PMC article.

6

Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput in silico screening.

Ferrie JJ, Lengyel-Zhand Z, Janssen B, Lougee MG, Giannakoulias S, Hsieh CJ, Pagar VV, Weng CC, Xu H, Graham TJA, Lee VM, Mach RH, Petersson EJ. Ferrie JJ, et al. Chem Sci. 2020 Sep 10;11(47):12746-12754. doi: 10.1039/d0sc02159h. eCollection 2020 Dec 21. Chem Sci. 2020. PMID: 33889379 Free PMC article.

7

Screening of σ₂ Receptor Ligands and In Vivo Evaluation of ¹¹C-Labeled 6,7-Dimethoxy-2-[4-(4-methoxyphenyl)butan-2-yl]-1,2,3,4-tetrahydroisoquinoline for Potential Use as a σ₂ Receptor Brain PET Tracer.

Kim HY, Lee JY, Hsieh CJ, Riad A, Izzo NJ, Catalano SM, Graham TJA, Mach RH. Kim HY, et al. J Med Chem. 2022 Apr 28;65(8):6261-6272. doi: 10.1021/acs.jmedchem.2c00191. Epub 2022 Apr 11. J Med Chem. 2022. PMID: 35404616

8

In Silico Discovery and Subsequent Characterization of Potent 4R-Tauopathy Positron Emission Tomography Radiotracers.

Graham TJA, Lindberg A, Tong J, Stehouwer JS, Vasdev N, Mach RH, Mathis CA. Graham TJA, et al. J Med Chem. 2023 Aug 10;66(15):10628-10638. doi: 10.1021/acs.jmedchem.3c00775. Epub 2023 Jul 24. J Med Chem. 2023. PMID: 37487189 Free PMC article.

9

A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy.

Kim HY, Chia WK, Hsieh CJ, Saturnino Guarino D, Graham TJA, Lengyel-Zhand Z, Schneider M, Tomita C, Lougee MG, Kim HJ, Pagar VV, Lee H, Hou C, Garcia BA, Petersson EJ, O'Shea J, Kotzbauer PT, Mathis CA, Lee VM, Luk KC, Mach RH. Kim HY, et al. Among authors: graham tja. J Med Chem. 2023 Sep 14;66(17):12185-12202. doi: 10.1021/acs.jmedchem.3c00779. Epub 2023 Aug 31. J Med Chem. 2023. PMID: 37651366 Free PMC article.

10

A Small-molecule Antagonist Radiotracer for Positron Emission Tomography Imaging of the Mu Opioid Receptor.

Plakas K, Hsieh CJ, Guarino DS, Hou C, Chia WK, Young A, Schmitz A, Ho YP, Weng CC, Lee H, Li S, Graham TJA, Mach RH. Plakas K, et al. Among authors: graham tja. bioRxiv [Preprint]. 2024 Oct 12:2024.10.12.618019. doi: 10.1101/2024.10.12.618019. bioRxiv. 2024. PMID: 39415998 Free PMC article. Preprint.

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