Pajvani UB - Search Results

1

Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver.

Kim K, Kang JK, Jung YH, Lee SB, Rametta R, Dongiovanni P, Valenti L, Pajvani UB. Kim K, et al. Among authors: pajvani ub. Nat Commun. 2021 Mar 23;12(1):1822. doi: 10.1038/s41467-021-22106-2. Nat Commun. 2021. PMID: 33758172 Free PMC article.

2

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.

Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D. Pajvani UB, et al. Nat Med. 2011 Jul 31;17(8):961-7. doi: 10.1038/nm.2378. Nat Med. 2011. PMID: 21804540 Free PMC article.

3

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.

Pajvani UB, Qiang L, Kangsamaksin T, Kitajewski J, Ginsberg HN, Accili D. Pajvani UB, et al. Nat Med. 2013 Aug;19(8):1054-60. doi: 10.1038/nm.3259. Epub 2013 Jul 7. Nat Med. 2013. PMID: 23832089 Free PMC article.

4

Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease.

Valenti L, Mendoza RM, Rametta R, Maggioni M, Kitajewski C, Shawber CJ, Pajvani UB. Valenti L, et al. Among authors: pajvani ub. Diabetes. 2013 Dec;62(12):4052-62. doi: 10.2337/db13-0769. Epub 2013 Aug 29. Diabetes. 2013. PMID: 23990360 Free PMC article.

5

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.

Kim K, Qiang L, Hayden MS, Sparling DP, Purcell NH, Pajvani UB. Kim K, et al. Among authors: pajvani ub. Nat Commun. 2016 Jan 8;7:10255. doi: 10.1038/ncomms10255. Nat Commun. 2016. PMID: 26743335 Free PMC article.

6

Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity.

Sparling DP, Yu J, Kim K, Zhu C, Brachs S, Birkenfeld AL, Pajvani UB. Sparling DP, et al. Among authors: pajvani ub. Mol Metab. 2015 Dec 2;5(2):113-121. doi: 10.1016/j.molmet.2015.11.006. eCollection 2016 Feb. Mol Metab. 2015. PMID: 26909319 Free PMC article.

7

"Free" Raptor - a novel regulator of metabolism.

Kim K, Pajvani UB. Kim K, et al. Among authors: pajvani ub. Cell Cycle. 2016 May 2;15(9):1174-5. doi: 10.1080/15384101.2016.1159835. Cell Cycle. 2016. PMID: 26987027 Free PMC article. No abstract available.

8

Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?

Valenti L, Bugianesi E, Pajvani U, Targher G. Valenti L, et al. Liver Int. 2016 Nov;36(11):1563-1579. doi: 10.1111/liv.13185. Epub 2016 Jun 30. Liver Int. 2016. PMID: 27276701 Free article. Review.

9

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.

Kim K, Ryu D, Dongiovanni P, Ozcan L, Nayak S, Ueberheide B, Valenti L, Auwerx J, Pajvani UB. Kim K, et al. Among authors: pajvani ub. Gastroenterology. 2017 Dec;153(6):1568-1580.e10. doi: 10.1053/j.gastro.2017.08.039. Epub 2017 Aug 30. Gastroenterology. 2017. PMID: 28859855 Free PMC article.

10

γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

Kim K, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, Pajvani UB. Kim K, et al. Among authors: pajvani ub. Cell Metab. 2018 Apr 3;27(4):816-827.e4. doi: 10.1016/j.cmet.2018.02.010. Epub 2018 Mar 22. Cell Metab. 2018. PMID: 29576536 Free PMC article.

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