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SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.
Mullen PJ, Garcia G Jr, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. Mullen PJ, et al. Among authors: purkayastha a. Nat Commun. 2021 Mar 25;12(1):1876. doi: 10.1038/s41467-021-22166-4. Nat Commun. 2021. PMID: 33767183 Free PMC article.
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery.
Mulay A, Konda B, Garcia G Jr, Yao C, Beil S, Sen C, Purkayastha A, Kolls JK, Pociask DA, Pessina P, de Aja JS, Garcia-de-Alba C, Kim CF, Gomperts B, Arumugaswami V, Stripp BR. Mulay A, et al. Among authors: purkayastha a. bioRxiv [Preprint]. 2020 Jun 29:2020.06.29.174623. doi: 10.1101/2020.06.29.174623. bioRxiv. 2020. Update in: Cell Rep. 2021 May 4;35(5):109055. doi: 10.1016/j.celrep.2021.109055. PMID: 32637946 Free PMC article. Updated. Preprint.
Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging.
Aros CJ, Vijayaraj P, Pantoja CJ, Bisht B, Meneses LK, Sandlin JM, Tse JA, Chen MW, Purkayastha A, Shia DW, Sucre JMS, Rickabaugh TM, Vladar EK, Paul MK, Gomperts BN. Aros CJ, et al. Among authors: purkayastha a. Cell Stem Cell. 2020 Sep 3;27(3):413-429.e4. doi: 10.1016/j.stem.2020.06.019. Epub 2020 Jul 27. Cell Stem Cell. 2020. PMID: 32721381 Free PMC article.
Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stem cell-derived airway repair response.
Purkayastha A, Sen C, Garcia G, Langerman J, Vijayaraj P, Shia DW, Meneses LK, Rickabaugh TM, Mulay A, Konda B, Sim MS, Stripp BR, Plath K, Arumugaswami V, Gomperts BN. Purkayastha A, et al. bioRxiv [Preprint]. 2020 Jul 29:2020.07.28.226092. doi: 10.1101/2020.07.28.226092. bioRxiv. 2020. Update in: Cell Stem Cell. 2020 Dec 3;27(6):869-875.e4. doi: 10.1016/j.stem.2020.11.010. PMID: 32766588 Free PMC article. Updated. Preprint.
Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response.
Purkayastha A, Sen C, Garcia G Jr, Langerman J, Shia DW, Meneses LK, Vijayaraj P, Durra A, Koloff CR, Freund DR, Chi J, Rickabaugh TM, Mulay A, Konda B, Sim MS, Stripp BR, Plath K, Arumugaswami V, Gomperts BN. Purkayastha A, et al. Cell Stem Cell. 2020 Dec 3;27(6):869-875.e4. doi: 10.1016/j.stem.2020.11.010. Epub 2020 Nov 17. Cell Stem Cell. 2020. PMID: 33259798 Free PMC article.
Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication.
Garcia G Jr, Sharma A, Ramaiah A, Sen C, Purkayastha A, Kohn DB, Parcells MS, Beck S, Kim H, Bakowski MA, Kirkpatrick MG, Riva L, Wolff KC, Han B, Yuen C, Ulmert D, Purbey PK, Scumpia P, Beutler N, Rogers TF, Chatterjee AK, Gabriel G, Bartenschlager R, Gomperts B, Svendsen CN, Betz UAK, Damoiseaux RD, Arumugaswami V. Garcia G Jr, et al. Among authors: purkayastha a. Cell Rep. 2021 Apr 6;35(1):108940. doi: 10.1016/j.celrep.2021.108940. Epub 2021 Mar 18. Cell Rep. 2021. PMID: 33784499 Free PMC article.
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery.
Mulay A, Konda B, Garcia G Jr, Yao C, Beil S, Villalba JM, Koziol C, Sen C, Purkayastha A, Kolls JK, Pociask DA, Pessina P, de Aja JS, Garcia-de-Alba C, Kim CF, Gomperts B, Arumugaswami V, Stripp BR. Mulay A, et al. Among authors: purkayastha a. Cell Rep. 2021 May 4;35(5):109055. doi: 10.1016/j.celrep.2021.109055. Epub 2021 Apr 13. Cell Rep. 2021. PMID: 33905739 Free PMC article.
Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition.
Carraro G, Langerman J, Sabri S, Lorenzana Z, Purkayastha A, Zhang G, Konda B, Aros CJ, Calvert BA, Szymaniak A, Wilson E, Mulligan M, Bhatt P, Lu J, Vijayaraj P, Yao C, Shia DW, Lund AJ, Israely E, Rickabaugh TM, Ernst J, Mense M, Randell SH, Vladar EK, Ryan AL, Plath K, Mahoney JE, Stripp BR, Gomperts BN. Carraro G, et al. Among authors: purkayastha a. Nat Med. 2021 May;27(5):806-814. doi: 10.1038/s41591-021-01332-7. Epub 2021 May 6. Nat Med. 2021. PMID: 33958799 Free PMC article.
Targeting PEA3 transcription factors to mitigate small cell lung cancer progression.
Shia DW, Choi W, Vijayaraj P, Vuong V, Sandlin JM, Lu MM, Aziz A, Marin C, Aros CJ, Sen C, Durra A, Lund AJ, Purkayastha A, Rickabaugh TM, Graeber TG, Gomperts BN. Shia DW, et al. Among authors: purkayastha a. Oncogene. 2023 Feb;42(6):434-448. doi: 10.1038/s41388-022-02558-6. Epub 2022 Dec 13. Oncogene. 2023. PMID: 36509998 Free PMC article.
104 results