Shen L - Search Results

1

Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy.

Liu C, Zhou F, Yan Z, Shen L, Zhang X, He F, Wang H, Lu X, Yu K, Zhao Y, Zhu D. Liu C, et al. Among authors: shen l. Br J Pharmacol. 2021 Jul;178(13):2651-2670. doi: 10.1111/bph.15457. Epub 2021 May 4. Br J Pharmacol. 2021. PMID: 33768523 Free article.

2

RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer.

Tian EM, Yu MC, Feng M, Lu LX, Liu CL, Shen LA, Wang YH, Xie Q, Zhu D. Tian EM, et al. Pharmacol Res. 2021 Oct;172:105793. doi: 10.1016/j.phrs.2021.105793. Epub 2021 Jul 31. Pharmacol Res. 2021. PMID: 34339836

3

RORγt agonist enhances anti-PD-1 therapy by promoting monocyte-derived dendritic cells through CXCL10 in cancers.

Xia L, Tian E, Yu M, Liu C, Shen L, Huang Y, Wu Z, Tian J, Yu K, Wang Y, Xie Q, Zhu D. Xia L, et al. Among authors: shen l. J Exp Clin Cancer Res. 2022 Apr 23;41(1):155. doi: 10.1186/s13046-022-02289-2. J Exp Clin Cancer Res. 2022. PMID: 35459193 Free PMC article.

4

Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers.

Xu Y, Wei Z, Feng M, Zhu D, Mei S, Wu Z, Feng Q, Chang W, Ji M, Liu C, Zhu Y, Shen L, Yang F, Chen Y, Feng Y, Xu J, Zhu D. Xu Y, et al. Among authors: shen l. Cell Rep. 2022 Aug 30;40(9):111295. doi: 10.1016/j.celrep.2022.111295. Cell Rep. 2022. PMID: 36044847 Free article.

5

Design, synthesis and biological evaluation of quercetin derivatives as novel β-catenin/B-cell lymphoma 9 protein-protein interaction inhibitors.

Shen LA, Peng X, Bao Y, Liu C, Zhang H, Li J, Zhu D, Zhang Q. Shen LA, et al. Eur J Med Chem. 2023 Feb 5;247:115075. doi: 10.1016/j.ejmech.2022.115075. Epub 2022 Dec 31. Eur J Med Chem. 2023. PMID: 36599228

6

Discovery of Novel 3-Phenylpiperidine Derivatives Targeting the β-Catenin/B-Cell Lymphoma 9 Interaction as a Single Agent and in Combination with the Anti-PD-1 Antibody for the Treatment of Colorectal Cancer.

Zhang H, Liu C, Chen Q, Shen LA, Xiao W, Li J, Wang Y, Zhu D, Zhang Q, Li J. Zhang H, et al. J Med Chem. 2023 Jan 26;66(2):1349-1379. doi: 10.1021/acs.jmedchem.2c01568. Epub 2023 Jan 11. J Med Chem. 2023. PMID: 36630177

7

Design, synthesis, and biological evaluation of novel 8-substituted quercetin derivatives targeting the β‑catenin/B-cell lymphoma 9 interaction.

Peng X, Shen LA, Bao Y, Liu C, Chen Q, Zhang H, Li J, Zhang Q. Peng X, et al. Bioorg Med Chem Lett. 2024 Jan 15;98:129591. doi: 10.1016/j.bmcl.2023.129591. Epub 2023 Dec 13. Bioorg Med Chem Lett. 2024. PMID: 38097141

8

Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting β-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells.

Zhu W, Liu C, Xi K, Li A, Shen LA, Li Y, Jia M, He Y, Chen G, Liu C, Chen Y, Chen K, Sun F, Zhang D, Duan C, Wang H, Wang D, Zhao Y, Meng X, Zhu D. Zhu W, et al. J Med Chem. 2024 Aug 8;67(15):12485-12520. doi: 10.1021/acs.jmedchem.3c02079. Epub 2024 Jun 24. J Med Chem. 2024. PMID: 38912577

9

Epoxymicheliolide Reduces Radiation-Induced Senescence and Extracellular Matrix Formation by Disrupting NF-κB and TGF-β/SMAD Pathways in Lung Cancer.

Zhou H, Chen Y, Jiang N, Ren Y, Zhuang J, Ren Y, Shen L, Li C. Zhou H, et al. Among authors: shen l. Phytother Res. 2024 Nov 6. doi: 10.1002/ptr.8352. Online ahead of print. Phytother Res. 2024. PMID: 39506320

10

The price of pressure: nationwide survey on lifestyle disturbances, occupational burnout and compromised perceived-competency among radiology residents in China.

Liu Z, Yao Q, Wang P, Shen L, Li H, Zhang J, Jiang M, Yang Z, Wang Z, Zheng J, Zhu J, Wu Y. Liu Z, et al. Among authors: shen l. Front Public Health. 2024 Oct 23;12:1472397. doi: 10.3389/fpubh.2024.1472397. eCollection 2024. Front Public Health. 2024. PMID: 39507651 Free PMC article.

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