Yu K - Search Results

1

Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy.

Liu C, Zhou F, Yan Z, Shen L, Zhang X, He F, Wang H, Lu X, Yu K, Zhao Y, Zhu D. Liu C, et al. Among authors: yu k. Br J Pharmacol. 2021 Jul;178(13):2651-2670. doi: 10.1111/bph.15457. Epub 2021 May 4. Br J Pharmacol. 2021. PMID: 33768523 Free article.

2

BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.

Wang X, Feng M, Xiao T, Guo B, Liu D, Liu C, Pei J, Liu Q, Xiao Y, Rosin-Arbesfeld R, Shi Y, Zhou Y, Yang M, Feng YX, Jiang Y, Shao Z, Yu K, Zhu D. Wang X, et al. Among authors: yu k. Oncogene. 2021 Apr;40(16):2982-2997. doi: 10.1038/s41388-021-01756-y. Epub 2021 Mar 25. Oncogene. 2021. PMID: 33767438

3

BCL9 regulates CD226 and CD96 checkpoints in CD8⁺ T cells to improve PD-1 response in cancer.

Feng M, Wu Z, Zhou Y, Wei Z, Tian E, Mei S, Zhu Y, Liu C, He F, Li H, Xie C, Jin J, Dong J, Yang D, Yu K, Qian J, Lambrechts D, Wang MW, Zhu D. Feng M, et al. Among authors: yu k. Signal Transduct Target Ther. 2021 Aug 20;6(1):313. doi: 10.1038/s41392-021-00730-0. Signal Transduct Target Ther. 2021. PMID: 34417435 Free PMC article.

4

LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo.

Liu Y, Lai M, Li S, Wang Y, Feng F, Zhang T, Tong L, Zhang M, Chen H, Chen Y, Song P, Li Y, Bai G, Ning Y, Tang H, Fang Y, Chen Y, Lu X, Geng M, Ding K, Yu K, Xie H, Ding J. Liu Y, et al. Among authors: yu k. Cancer Sci. 2022 Feb;113(2):709-720. doi: 10.1111/cas.15229. Epub 2021 Dec 16. Cancer Sci. 2022. PMID: 34855271 Free PMC article.

5

RORγt agonist enhances anti-PD-1 therapy by promoting monocyte-derived dendritic cells through CXCL10 in cancers.

Xia L, Tian E, Yu M, Liu C, Shen L, Huang Y, Wu Z, Tian J, Yu K, Wang Y, Xie Q, Zhu D. Xia L, et al. Among authors: yu m, yu k. J Exp Clin Cancer Res. 2022 Apr 23;41(1):155. doi: 10.1186/s13046-022-02289-2. J Exp Clin Cancer Res. 2022. PMID: 35459193 Free PMC article.

6

Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.

Li QR, Zhao H, Zhang XS, Lang H, Yu K. Li QR, et al. Among authors: yu k. Acta Pharmacol Sin. 2019 Feb;40(2):257-267. doi: 10.1038/s41401-018-0019-5. Epub 2018 May 18. Acta Pharmacol Sin. 2019. PMID: 29777201 Free PMC article.

7

A Novel mTORC1/2 Inhibitor (MTI-31) Inhibits Tumor Growth, Epithelial-Mesenchymal Transition, Metastases, and Improves Antitumor Immunity in Preclinical Models of Lung Cancer.

Zhang Q, Zhang Y, Chen Y, Qian J, Zhang X, Yu K. Zhang Q, et al. Among authors: yu k. Clin Cancer Res. 2019 Jun 15;25(12):3630-3642. doi: 10.1158/1078-0432.CCR-18-2548. Epub 2019 Feb 22. Clin Cancer Res. 2019. PMID: 30796032

8

Non-immunogenic, low-toxicity and effective glioma targeting MTI-31 liposomes.

Wang X, Meng N, Wang S, Zhang Y, Lu L, Wang R, Ruan H, Jiang K, Wang H, Ran D, Zhan C, Yu K, Burgess DJ, Lu W. Wang X, et al. Among authors: yu k. J Control Release. 2019 Dec 28;316:381-392. doi: 10.1016/j.jconrel.2019.11.005. Epub 2019 Nov 12. J Control Release. 2019. PMID: 31730912

9

Dual Mechanisms of Novel CD73-Targeted Antibody and Antibody-Drug Conjugate in Inhibiting Lung Tumor Growth and Promoting Antitumor Immune-Effector Function.

Jin R, Liu L, Xing Y, Meng T, Ma L, Pei J, Cong Y, Zhang X, Ren Z, Wang X, Shen J, Yu K. Jin R, et al. Among authors: yu k. Mol Cancer Ther. 2020 Nov;19(11):2340-2352. doi: 10.1158/1535-7163.MCT-20-0076. Epub 2020 Sep 17. Mol Cancer Ther. 2020. PMID: 32943546

10

Therapeutic efficacy and mechanism of CD73-TGFβ dual-blockade in a mouse model of triple-negative breast cancer.

Xing Y, Ren ZQ, Jin R, Liu L, Pei JP, Yu K. Xing Y, et al. Among authors: yu k. Acta Pharmacol Sin. 2022 Sep;43(9):2410-2418. doi: 10.1038/s41401-021-00840-z. Epub 2022 Jan 26. Acta Pharmacol Sin. 2022. PMID: 35082394 Free PMC article.

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