Zhao Y - Search Results

1

Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy.

Liu C, Zhou F, Yan Z, Shen L, Zhang X, He F, Wang H, Lu X, Yu K, Zhao Y, Zhu D. Liu C, et al. Among authors: zhao y. Br J Pharmacol. 2021 Jul;178(13):2651-2670. doi: 10.1111/bph.15457. Epub 2021 May 4. Br J Pharmacol. 2021. PMID: 33768523 Free article.

2

Allenamide as a bioisostere of acrylamide in the design and synthesis of targeted covalent inhibitors.

Chen D, Guo D, Yan Z, Zhao Y. Chen D, et al. Among authors: zhao y. Medchemcomm. 2017 Dec 11;9(2):244-253. doi: 10.1039/c7md00571g. eCollection 2018 Feb 1. Medchemcomm. 2017. PMID: 30108918 Free PMC article.

3

Lewis Acids Promoted 3 + 2 Cycloaddition of Oxaziridines and Cyclic Allylic Alcohols through Carbonyl Imine Intermediates.

Zhao E, Zhou F, Zhao Y. Zhao E, et al. Among authors: zhao y. J Org Chem. 2019 Apr 5;84(7):4282-4293. doi: 10.1021/acs.joc.9b00246. Epub 2019 Mar 25. J Org Chem. 2019. PMID: 30869515

4

Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins.

Chen D, Lu T, Yan Z, Lu W, Zhou F, Lyu X, Xu B, Jiang H, Chen K, Luo C, Zhao Y. Chen D, et al. Among authors: zhao y. Eur J Med Chem. 2019 Nov 15;182:111633. doi: 10.1016/j.ejmech.2019.111633. Epub 2019 Aug 21. Eur J Med Chem. 2019. PMID: 31461688

5

Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo.

Li Z, Li X, Su MB, Gao LX, Zhou YB, Yuan B, Lyu X, Yan Z, Hu C, Zhang H, Luo C, Chen Z, Li J, Zhao Y. Li Z, et al. Among authors: zhao y. J Med Chem. 2020 Apr 23;63(8):4388-4407. doi: 10.1021/acs.jmedchem.0c00396. Epub 2020 Apr 7. J Med Chem. 2020. PMID: 32216342

6

Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases.

Cheng J, Feng X, Li Z, Zhou F, Yang JM, Zhao Y. Cheng J, et al. Among authors: zhao y. RSC Med Chem. 2021 Jan 22;12(4):552-565. doi: 10.1039/d0md00361a. eCollection 2021 Apr 28. RSC Med Chem. 2021. PMID: 34046627 Free PMC article. Review.

7

Diversified strategy for the synthesis of DNA-encoded oxindole libraries.

Wang X, Liu J, Yan Z, Liu X, Liu S, Suo Y, Lu W, Yue J, Chen K, Jiang H, Zhao Y, Zheng M, Dai D, Lu X. Wang X, et al. Among authors: zhao y. Chem Sci. 2021 Jan 4;12(8):2841-2847. doi: 10.1039/d0sc06696f. Chem Sci. 2021. PMID: 34164048 Free PMC article.

8

Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions.

Zhang S, Lou J, Li Y, Zhou F, Yan Z, Lyu X, Zhao Y. Zhang S, et al. Among authors: zhao y. J Med Chem. 2021 Aug 12;64(15):10621-10640. doi: 10.1021/acs.jmedchem.1c00940. Epub 2021 Jul 21. J Med Chem. 2021. PMID: 34286973 Review.

9

Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells.

Feng X, Yan Z, Zhou F, Lou J, Lyu X, Ren X, Zeng Z, Liu C, Zhang S, Zhu D, Huang H, Yang J, Zhao Y. Feng X, et al. Among authors: zhao y. Eur J Med Chem. 2022 Jun 5;236:114327. doi: 10.1016/j.ejmech.2022.114327. Epub 2022 Mar 29. Eur J Med Chem. 2022. PMID: 35385805

10

Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.

Zhang S, Yan Z, Li Y, Gong Y, Lyu X, Lou J, Zhang D, Meng X, Zhao Y. Zhang S, et al. Among authors: zhao y. J Med Chem. 2022 Apr 28;65(8):6207-6230. doi: 10.1021/acs.jmedchem.2c00095. Epub 2022 Apr 14. J Med Chem. 2022. PMID: 35420431

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