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SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2.
Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. Lei Y, et al. Among authors: shadel gs. Circ Res. 2021 Apr 30;128(9):1323-1326. doi: 10.1161/CIRCRESAHA.121.318902. Epub 2021 Mar 31. Circ Res. 2021. PMID: 33784827 Free PMC article. No abstract available.
Actin chromobody imaging reveals sub-organellar actin dynamics.
Schiavon CR, Zhang T, Zhao B, Moore AS, Wales P, Andrade LR, Wu M, Sung TC, Dayn Y, Feng JW, Quintero OA, Shadel GS, Grosse R, Manor U. Schiavon CR, et al. Among authors: shadel gs. Nat Methods. 2020 Sep;17(9):917-921. doi: 10.1038/s41592-020-0926-5. Epub 2020 Aug 10. Nat Methods. 2020. PMID: 32778832 Free PMC article.
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2.
Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. Lei Y, et al. Among authors: shadel gs. bioRxiv [Preprint]. 2020 Dec 4:2020.12.04.409144. doi: 10.1101/2020.12.04.409144. bioRxiv. 2020. Update in: Circ Res. 2021 Apr 30;128(9):1323-1326. doi: 10.1161/CIRCRESAHA.121.318902. PMID: 33300001 Free PMC article. Updated. Preprint.
Impaired Mitochondrial Mobility in Charcot-Marie-Tooth Disease.
Schiavon CR, Shadel GS, Manor U. Schiavon CR, et al. Among authors: shadel gs. Front Cell Dev Biol. 2021 Feb 1;9:624823. doi: 10.3389/fcell.2021.624823. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33598463 Free PMC article.
The San Diego Nathan Shock Center: tackling the heterogeneity of aging.
Shadel GS, Adams PD, Berggren WT, Diedrich JK, Diffenderfer KE, Gage FH, Hah N, Hansen M, Hetzer MW, Molina AJA, Manor U, Marek K, O'Keefe DD, Pinto AFM, Sacco A, Sharpee TO, Shokriev MN, Zambetti S. Shadel GS, et al. Geroscience. 2021 Oct;43(5):2139-2148. doi: 10.1007/s11357-021-00426-x. Epub 2021 Aug 9. Geroscience. 2021. PMID: 34370163 Free PMC article.
Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions.
Hepokoski ML, Odish M, Lam MT, Coufal NG, Rolfsen ML, Shadel GS, Moyzis AG, Sainz AG, Takiar PG, Patel S, Leonard AJ, Samandari N, Hansen E, Trescott S, Nguyen C, Jepsen K, Cutter G, Gillespie MN, Spragg RG, Sasik R, Ix JH. Hepokoski ML, et al. Among authors: shadel gs. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L84-L92. doi: 10.1152/ajplung.00128.2022. Epub 2022 Jun 14. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35699291 Free PMC article.
Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1.
Malik N, Ferreira BI, Hollstein PE, Curtis SD, Trefts E, Weiser Novak S, Yu J, Gilson R, Hellberg K, Fang L, Sheridan A, Hah N, Shadel GS, Manor U, Shaw RJ. Malik N, et al. Among authors: shadel gs. Science. 2023 Apr 21;380(6642):eabj5559. doi: 10.1126/science.abj5559. Epub 2023 Apr 21. Science. 2023. PMID: 37079666 Free PMC article.
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal.
Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S, Rodriguez-Enriquez R, Chevez JA, Lemersal I, Manor U, Shadel GS. Newman LE, et al. Among authors: shadel gs. Nat Cell Biol. 2024 Feb;26(2):194-206. doi: 10.1038/s41556-023-01343-1. Epub 2024 Feb 8. Nat Cell Biol. 2024. PMID: 38332353
150 results