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ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer.
Olsen RR, Ireland AS, Kastner DW, Groves SM, Spainhower KB, Pozo K, Kelenis DP, Whitney CP, Guthrie MR, Wait SJ, Soltero D, Witt BL, Quaranta V, Johnson JE, Oliver TG. Olsen RR, et al. Among authors: groves sm. Genes Dev. 2021 Jun;35(11-12):847-869. doi: 10.1101/gad.348295.121. Epub 2021 May 20. Genes Dev. 2021. PMID: 34016693 Free PMC article.
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities.
Gay CM, Stewart CA, Park EM, Diao L, Groves SM, Heeke S, Nabet BY, Fujimoto J, Solis LM, Lu W, Xi Y, Cardnell RJ, Wang Q, Fabbri G, Cargill KR, Vokes NI, Ramkumar K, Zhang B, Della Corte CM, Robson P, Swisher SG, Roth JA, Glisson BS, Shames DS, Wistuba II, Wang J, Quaranta V, Minna J, Heymach JV, Byers LA. Gay CM, et al. Among authors: groves sm. Cancer Cell. 2021 Mar 8;39(3):346-360.e7. doi: 10.1016/j.ccell.2020.12.014. Epub 2021 Jan 21. Cancer Cell. 2021. PMID: 33482121 Free PMC article.
Beyond Programmed Death-Ligand 1: B7-H6 Emerges as a Potential Immunotherapy Target in SCLC.
Thomas PL, Groves SM, Zhang YK, Li J, Gonzalez-Ericsson P, Sivagnanam S, Betts CB, Chen HC, Liu Q, Lowe C, Chen H, Boyd KL, Kopparapu PR, Yan Y, Coussens LM, Quaranta V, Tyson DR, Iams W, Lovly CM. Thomas PL, et al. Among authors: groves sm. J Thorac Oncol. 2021 Jul;16(7):1211-1223. doi: 10.1016/j.jtho.2021.03.011. Epub 2021 Apr 8. J Thorac Oncol. 2021. PMID: 33839362 Free PMC article.
Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer.
Groves SM, Ildefonso GV, McAtee CO, Ozawa PMM, Ireland AS, Stauffer PE, Wasdin PT, Huang X, Qiao Y, Lim JS, Bader J, Liu Q, Simmons AJ, Lau KS, Iams WT, Hardin DP, Saff EB, Holmes WR, Tyson DR, Lovly CM, Rathmell JC, Marth G, Sage J, Oliver TG, Weaver AM, Quaranta V. Groves SM, et al. Cell Syst. 2022 Sep 21;13(9):690-710.e17. doi: 10.1016/j.cels.2022.07.006. Epub 2022 Aug 17. Cell Syst. 2022. PMID: 35981544 Free PMC article.
Proteome-wide copy-number estimation from transcriptomics.
Sweatt AJ, Griffiths CD, Groves SM, Paudel BB, Wang L, Kashatus DF, Janes KA. Sweatt AJ, et al. Among authors: groves sm. Mol Syst Biol. 2024 Nov;20(11):1230-1256. doi: 10.1038/s44320-024-00064-3. Epub 2024 Sep 27. Mol Syst Biol. 2024. PMID: 39333715 Free PMC article.
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