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The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape.
Nat Immunol. 2021 Jun;22(6):769-780. doi: 10.1038/s41590-021-00931-3. Epub 2021 May 20.
Nat Immunol. 2021.
PMID: 34017122
Clinical Trial.
A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML.
Chen L, Pronk E, van Dijk C, Bian Y, Feyen J, van Tienhoven T, Yildirim M, Pisterzi P, de Jong MME, Bastidas A, Hoogenboezem RM, Wevers C, Bindels EM, Löwenberg B, Cupedo T, Sanders MA, Raaijmakers MHGP.
Chen L, et al. Among authors: de jong mme.
Blood Cancer Discov. 2023 Sep 1;4(5):394-417. doi: 10.1158/2643-3230.BCD-23-0043.
Blood Cancer Discov. 2023.
PMID: 37470778
Free PMC article.
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Bone marrow inflammation in haematological malignancies.
de Jong MME, Chen L, Raaijmakers MHGP, Cupedo T.
de Jong MME, et al.
Nat Rev Immunol. 2024 Aug;24(8):543-558. doi: 10.1038/s41577-024-01003-x. Epub 2024 Mar 15.
Nat Rev Immunol. 2024.
PMID: 38491073
Review.
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An IL-1β-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma.
de Jong MME, Fokkema C, Papazian N, Czeti Á, Appelman MK, Vermeulen M, van Heusden T, Hoogenboezem RM, van Beek G, Tahri S, Sanders MA, van de Woestijne PC, Gay F, Moreau P, Büttner-Herold M, Bruns H, van Duin M, Broijl A, Sonneveld P, Cupedo T.
de Jong MME, et al.
Nat Immunol. 2024 May;25(5):820-833. doi: 10.1038/s41590-024-01808-x. Epub 2024 Apr 10.
Nat Immunol. 2024.
PMID: 38600356
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