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Inclusion of a short hairpin RNA targeting BCL11A into a β-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin.
Pires Lourenco S, Jarocha D, Ghiaccio V, Guerra A, Abdulmalik O, La P, Zezulin A, Smith-Whitley K, Kwiatkowski JL, Guzikowski V, Nakamura Y, Raabe T, Breda L, Rivella S. Pires Lourenco S, et al. Among authors: rivella s. Haematologica. 2021 Oct 1;106(10):2740-2745. doi: 10.3324/haematol.2020.276634. Haematologica. 2021. PMID: 34047176 Free PMC article. No abstract available.
Protective role of calreticulin in HFE hemochromatosis.
Pinto JP, Ramos P, de Almeida SF, Oliveira S, Breda L, Michalak M, Porto G, Rivella S, de Sousa M. Pinto JP, et al. Among authors: rivella s. Free Radic Biol Med. 2008 Jan 1;44(1):99-108. doi: 10.1016/j.freeradbiomed.2007.09.014. Epub 2007 Oct 4. Free Radic Biol Med. 2008. PMID: 18045552
Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassaemia mutation for the screening of correctors of stop-codon mutations.
Salvatori F, Cantale V, Breveglieri G, Zuccato C, Finotti A, Bianchi N, Borgatti M, Feriotto G, Destro F, Canella A, Breda L, Rivella S, Gambari R. Salvatori F, et al. Among authors: rivella s. Biotechnol Appl Biochem. 2009 Jul 9;54(1):41-52. doi: 10.1042/BA20080266. Biotechnol Appl Biochem. 2009. PMID: 19216718 Free PMC article.
Production of beta-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous beta(0)39 thalassemia patients.
Salvatori F, Breveglieri G, Zuccato C, Finotti A, Bianchi N, Borgatti M, Feriotto G, Destro F, Canella A, Brognara E, Lampronti I, Breda L, Rivella S, Gambari R. Salvatori F, et al. Among authors: rivella s. Am J Hematol. 2009 Nov;84(11):720-8. doi: 10.1002/ajh.21539. Am J Hematol. 2009. PMID: 19810011 Free PMC article.
A preclinical approach for gene therapy of beta-thalassemia.
Breda L, Kleinert DA, Casu C, Casula L, Cartegni L, Fibach E, Mancini I, Giardina PJ, Gambari R, Rivella S. Breda L, et al. Among authors: rivella s. Ann N Y Acad Sci. 2010 Aug;1202:134-40. doi: 10.1111/j.1749-6632.2010.05594.x. Ann N Y Acad Sci. 2010. PMID: 20712784 Free PMC article.
Gene therapy in thalassemia and hemoglobinopathies.
Breda L, Gambari R, Rivella S. Breda L, et al. Among authors: rivella s. Mediterr J Hematol Infect Dis. 2009 Nov 13;1(1):e2009008. doi: 10.4084/MJHID.2009.008. Mediterr J Hematol Infect Dis. 2009. PMID: 21415990 Free PMC article.
Gene therapy for hemoglobinopathies: progress and challenges.
Dong A, Rivella S, Breda L. Dong A, et al. Among authors: rivella s. Transl Res. 2013 Apr;161(4):293-306. doi: 10.1016/j.trsl.2012.12.011. Epub 2013 Jan 19. Transl Res. 2013. PMID: 23337292 Free PMC article. Review.
157 results