Chen L - Search Results

1

Exploring the stability of inhibitor binding to SIK2 using molecular dynamics simulation and binding free energy calculation.

Shi M, Zhao M, Wang L, Liu K, Li P, Liu J, Cai X, Chen L, Xu D. Shi M, et al. Among authors: chen l. Phys Chem Chem Phys. 2021 Jun 16;23(23):13216-13227. doi: 10.1039/d1cp00717c. Phys Chem Chem Phys. 2021. PMID: 34086021

2

Correlation between biological activity and binding energy in systems of integrin with cyclic RGD-containing binders: a QM/MM molecular dynamics study.

Xiang M, Lin Y, He G, Chen L, Yang M, Yang S, Mo Y. Xiang M, et al. Among authors: chen l. J Mol Model. 2012 Nov;18(11):4917-27. doi: 10.1007/s00894-012-1487-z. Epub 2012 Jun 27. J Mol Model. 2012. PMID: 22736220

3

Identification, characterization and HPLC quantification of formulation-related impurities of honokiol, an antitumor natural drug candidate in clinical trials.

Wu W, Tang MH, Tang H, Chen K, Fu J, Wang L, Xue LL, Peng A, Ye H, Chen LJ. Wu W, et al. Among authors: chen k, chen lj. J Pharm Biomed Anal. 2018 May 10;153:186-192. doi: 10.1016/j.jpba.2018.02.033. Epub 2018 Feb 21. J Pharm Biomed Anal. 2018. PMID: 29499462

4

Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.

Li Y, Xiong Y, Zhang G, Zhang L, Yang W, Yang J, Huang L, Qiao Z, Miao Z, Lin G, Sun Q, Niu T, Chen L, Niu D, Li L, Yang S. Li Y, et al. Among authors: chen l. J Med Chem. 2018 Dec 27;61(24):11398-11414. doi: 10.1021/acs.jmedchem.8b01652. Epub 2018 Dec 10. J Med Chem. 2018. PMID: 30480444

5

Flavonoids from the stems of Millettia pachyloba Drake mediate cytotoxic activity through apoptosis and autophagy in cancer cells.

Yan W, Yang J, Tang H, Xue L, Chen K, Wang L, Zhao M, Tang M, Peng A, Long C, Chen X, Ye H, Chen L. Yan W, et al. Among authors: chen k, chen l, chen x. J Adv Res. 2019 Jun 21;20:117-127. doi: 10.1016/j.jare.2019.06.002. eCollection 2019 Nov. J Adv Res. 2019. PMID: 31338224 Free PMC article.

6

Anti-inflammatory Ellagitannins from Cleidion brevipetiolatum for the Treatment of Rheumatoid Arthritis.

Zhao M, Yuan X, Pei YH, Ye HY, Peng AH, Tang MH, Guo DL, Deng Y, Chen LJ. Zhao M, et al. J Nat Prod. 2019 Sep 27;82(9):2409-2418. doi: 10.1021/acs.jnatprod.8b00984. Epub 2019 Aug 16. J Nat Prod. 2019. PMID: 31419126

7

Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity.

Niu L, Yang J, Yan W, Yu Y, Zheng Y, Ye H, Chen Q, Chen L. Niu L, et al. Among authors: chen l, chen q. J Biol Chem. 2019 Nov 29;294(48):18099-18108. doi: 10.1074/jbc.RA119.010732. Epub 2019 Oct 18. J Biol Chem. 2019. PMID: 31628188 Free PMC article.

8

Discovery of Potent and Orally Effective Dual Janus Kinase 2/FLT3 Inhibitors for the Treatment of Acute Myelogenous Leukemia and Myeloproliferative Neoplasms.

Yang T, Hu M, Qi W, Yang Z, Tang M, He J, Chen Y, Bai P, Yuan X, Zhang C, Liu K, Lu Y, Xiang M, Chen L. Yang T, et al. Among authors: chen l, chen y. J Med Chem. 2019 Nov 27;62(22):10305-10320. doi: 10.1021/acs.jmedchem.9b01348. Epub 2019 Nov 8. J Med Chem. 2019. PMID: 31670517

9

Alkaloids from Black Pepper (Piper nigrum L.) Exhibit Anti-Inflammatory Activity in Murine Macrophages by Inhibiting Activation of NF-κB Pathway.

Pei H, Xue L, Tang M, Tang H, Kuang S, Wang L, Ma X, Cai X, Li Y, Zhao M, Peng A, Ye H, Chen L. Pei H, et al. Among authors: chen l. J Agric Food Chem. 2020 Feb 26;68(8):2406-2417. doi: 10.1021/acs.jafc.9b07754. Epub 2020 Feb 18. J Agric Food Chem. 2020. PMID: 32031370

10

Modulation of LPS-induced inflammation in RAW264.7 murine cells by novel isoflavonoids from Millettia pulchra.

Xue LL, Wu WS, Ma X, Pei HY, Tang MH, Kuang S, Cai XY, Wang L, Li Y, Zhang RJ, Hong F, Peng AH, Ye HY, Chen LJ. Xue LL, et al. Among authors: chen lj. Bioorg Chem. 2020 Apr;97:103693. doi: 10.1016/j.bioorg.2020.103693. Epub 2020 Feb 22. Bioorg Chem. 2020. PMID: 32120079

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