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The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models.
Stegmann KM, Dickmanns A, Gerber S, Nikolova V, Klemke L, Manzini V, Schlösser D, Bierwirth C, Freund J, Sitte M, Lugert R, Salinas G, Meister TL, Pfaender S, Görlich D, Wollnik B, Groß U, Dobbelstein M. Stegmann KM, et al. Among authors: bierwirth c. Virus Res. 2021 Sep;302:198469. doi: 10.1016/j.virusres.2021.198469. Epub 2021 Jun 6. Virus Res. 2021. PMID: 34090962 Free PMC article.
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity.
Köpper F, Bierwirth C, Schön M, Kunze M, Elvers I, Kranz D, Saini P, Menon MB, Walter D, Sørensen CS, Gaestel M, Helleday T, Schön MP, Dobbelstein M. Köpper F, et al. Among authors: bierwirth c. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16856-61. doi: 10.1073/pnas.1304355110. Epub 2013 Sep 30. Proc Natl Acad Sci U S A. 2013. PMID: 24082115 Free PMC article.
Elevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillations.
Stadler K, Bierwirth C, Stoenica L, Battefeld A, Reetz O, Mix E, Schuchmann S, Velmans T, Rosenberger K, Bräuer AU, Lehnardt S, Nitsch R, Budt M, Wolff T, Kole MH, Strauss U. Stadler K, et al. Among authors: bierwirth c. Cereb Cortex. 2014 Jan;24(1):199-210. doi: 10.1093/cercor/bhs305. Epub 2012 Oct 4. Cereb Cortex. 2014. PMID: 23042740