Wang Y - Search Results

1

Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer.

Xiang W, Zhao L, Han X, Qin C, Miao B, McEachern D, Wang Y, Metwally H, Kirchhoff PD, Wang L, Matvekas A, He M, Wen B, Sun D, Wang S. Xiang W, et al. Among authors: wang l, wang y, wang s. J Med Chem. 2021 Sep 23;64(18):13487-13509. doi: 10.1021/acs.jmedchem.1c00900. Epub 2021 Sep 2. J Med Chem. 2021. PMID: 34473519 Free PMC article.

2

Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer.

Han X, Zhao L, Xiang W, Qin C, Miao B, McEachern D, Wang Y, Metwally H, Wang L, Matvekas A, Wen B, Sun D, Wang S. Han X, et al. Among authors: wang l, wang y, wang s. J Med Chem. 2021 Sep 9;64(17):12831-12854. doi: 10.1021/acs.jmedchem.1c00882. Epub 2021 Aug 25. J Med Chem. 2021. PMID: 34431670 Free PMC article.

3

Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.

Zhang M, Aguilar A, Xu S, Huang L, Chinnaswamy K, Sleger T, Wang B, Gross S, Nicolay BN, Ronseaux S, Harvey K, Wang Y, McEachern D, Kirchhoff PD, Liu Z, Stuckey J, Tron AE, Liu T, Wang S. Zhang M, et al. Among authors: wang y, wang s, wang b. J Med Chem. 2021 Jul 22;64(14):10333-10349. doi: 10.1021/acs.jmedchem.1c00789. Epub 2021 Jul 1. J Med Chem. 2021. PMID: 34196551 Free PMC article.

4

Synthesis and evaluation of biological and antitumor activities of 5,7-dimethyl- oxazolo[5,4-d]pyrimidine-4,6(5H,7H)-dione derivatives as novel inhibitors of FGFR1.

Ye F, Wang Y, Nian S, Wang Y, Chen D, Yu S, Wang S. Ye F, et al. Among authors: wang y, wang s. J Enzyme Inhib Med Chem. 2015 Dec;30(6):961-6. doi: 10.3109/14756366.2014.1002401. Epub 2015 Feb 16. J Enzyme Inhib Med Chem. 2015. PMID: 25683078

5

Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia.

Wu Y, Zhou Q, Zhang T, Li Z, Chen YP, Zhang P, Yu YF, Geng H, Tian YJ, Zhang C, Wang Y, Chen JW, Chen Y, Luo HB. Wu Y, et al. Among authors: wang y. J Med Chem. 2019 Apr 25;62(8):4218-4224. doi: 10.1021/acs.jmedchem.8b01041. Epub 2019 Apr 3. J Med Chem. 2019. PMID: 30916555

6

Design and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazol-3-yl)pyridines as potential antitumor agents.

Qin M, Zhai X, Xie H, Ma J, Lu K, Wang Y, Wang L, Gu Y, Gong P. Qin M, et al. Among authors: wang l, wang y. Eur J Med Chem. 2014 Jun 23;81:47-58. doi: 10.1016/j.ejmech.2014.04.059. Epub 2014 Apr 24. Eur J Med Chem. 2014. PMID: 24826815

7

Design, synthesis and biological evaluation of novel 4-arylaminopyrimidine derivatives possessing a hydrazone moiety as dual inhibitors of L1196M ALK and ROS1.

Wang Y, Zhang G, Hu G, Bu Y, Lei H, Zuo D, Han M, Zhai X, Gong P. Wang Y, et al. Eur J Med Chem. 2016 Nov 10;123:80-89. doi: 10.1016/j.ejmech.2016.06.056. Epub 2016 Jul 12. Eur J Med Chem. 2016. PMID: 27474925

8

Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives containing diaryl urea moiety as potent antitumor agents.

Liu Z, Wang Y, Lin H, Zuo D, Wang L, Zhao Y, Gong P. Liu Z, et al. Among authors: wang l, wang y. Eur J Med Chem. 2014 Oct 6;85:215-27. doi: 10.1016/j.ejmech.2014.07.099. Epub 2014 Jul 28. Eur J Med Chem. 2014. PMID: 25086238

9

A naphthyridine-indole ligand for selective stabilization of G-quadruplexes and conformational conversion of hybrid topology.

Wang Y, Li C, Hao X, Wang L, Ma X, Jin R, Kang C, Gao L. Wang Y, et al. Among authors: wang l. Bioorg Med Chem. 2021 Oct 15;48:116416. doi: 10.1016/j.bmc.2021.116416. Epub 2021 Sep 20. Bioorg Med Chem. 2021. PMID: 34560615

10

Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.

Wang Z, Jiang X, Zhang X, Tian G, Yang R, Wu J, Zou X, Liu Z, Yang X, Wu C, Shi J, Li J, Suo J, Wang Y, Zhang R, Xu Z, Gong X, He Y, Zhu W, Aisa HA, Jiang H, Xu Y, Shen J. Wang Z, et al. Among authors: wang y. J Med Chem. 2019 May 23;62(10):4979-4990. doi: 10.1021/acs.jmedchem.9b00123. Epub 2019 May 8. J Med Chem. 2019. PMID: 31021628

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