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Page 1
Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors.
Burger ML, Cruz AM, Crossland GE, Gaglia G, Ritch CC, Blatt SE, Bhutkar A, Canner D, Kienka T, Tavana SZ, Barandiaran AL, Garmilla A, Schenkel JM, Hillman M, de Los Rios Kobara I, Li A, Jaeger AM, Hwang WL, Westcott PMK, Manos MP, Holovatska MM, Hodi FS, Regev A, Santagata S, Jacks T. Burger ML, et al. Among authors: westcott pmk. Cell. 2021 Sep 16;184(19):4996-5014.e26. doi: 10.1016/j.cell.2021.08.020. Cell. 2021. PMID: 34534464 Free PMC article.
Identification of DHODH as a therapeutic target in small cell lung cancer.
Li L, Ng SR, Colón CI, Drapkin BJ, Hsu PP, Li Z, Nabel CS, Lewis CA, Romero R, Mercer KL, Bhutkar A, Phat S, Myers DT, Muzumdar MD, Westcott PMK, Beytagh MC, Farago AF, Vander Heiden MG, Dyson NJ, Jacks T. Li L, et al. Among authors: westcott pmk. Sci Transl Med. 2019 Nov 6;11(517):eaaw7852. doi: 10.1126/scitranslmed.aaw7852. Sci Transl Med. 2019. PMID: 31694929 Free PMC article.
Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling.
Kirkpatrick JD, Warren AD, Soleimany AP, Westcott PMK, Voog JC, Martin-Alonso C, Fleming HE, Tammela T, Jacks T, Bhatia SN. Kirkpatrick JD, et al. Among authors: westcott pmk. Sci Transl Med. 2020 Apr 1;12(537):eaaw0262. doi: 10.1126/scitranslmed.aaw0262. Sci Transl Med. 2020. PMID: 32238573 Free PMC article.
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
LaFave LM, Kartha VK, Ma S, Meli K, Del Priore I, Lareau C, Naranjo S, Westcott PMK, Duarte FM, Sankar V, Chiang Z, Brack A, Law T, Hauck H, Okimoto A, Regev A, Buenrostro JD, Jacks T. LaFave LM, et al. Among authors: westcott pmk. Cancer Cell. 2020 Aug 10;38(2):212-228.e13. doi: 10.1016/j.ccell.2020.06.006. Epub 2020 Jul 23. Cancer Cell. 2020. PMID: 32707078 Free PMC article.
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer.
Freed-Pastor WA, Lambert LJ, Ely ZA, Pattada NB, Bhutkar A, Eng G, Mercer KL, Garcia AP, Lin L, Rideout WM 3rd, Hwang WL, Schenkel JM, Jaeger AM, Bronson RT, Westcott PMK, Hether TD, Divakar P, Reeves JW, Deshpande V, Delorey T, Phillips D, Yilmaz OH, Regev A, Jacks T. Freed-Pastor WA, et al. Among authors: westcott pmk. Cancer Cell. 2021 Oct 11;39(10):1342-1360.e14. doi: 10.1016/j.ccell.2021.07.007. Epub 2021 Aug 5. Cancer Cell. 2021. PMID: 34358448 Free PMC article.
Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1.
Romero R, Sánchez-Rivera FJ, Westcott PMK, Mercer KL, Bhutkar A, Muir A, González Robles TJ, Lamboy Rodríguez S, Liao LZ, Ng SR, Li L, Colón CI, Naranjo S, Beytagh MC, Lewis CA, Hsu PP, Bronson RT, Vander Heiden MG, Jacks T. Romero R, et al. Among authors: westcott pmk. Nat Cancer. 2020 Jun;1(6):589-602. doi: 10.1038/s43018-020-0071-1. Epub 2020 Jun 8. Nat Cancer. 2020. PMID: 34414377 Free PMC article.
Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes.
Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan SL, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, Park JK, Burger ML, Rozenblatt-Rosen O, Cong L, Pauken KE, Regev A, Jacks T. Schenkel JM, et al. Immunity. 2021 Oct 12;54(10):2338-2353.e6. doi: 10.1016/j.immuni.2021.08.026. Epub 2021 Sep 16. Immunity. 2021. PMID: 34534439 Free PMC article.
Smarca4 Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung.
Concepcion CP, Ma S, LaFave LM, Bhutkar A, Liu M, DeAngelo LP, Kim JY, Del Priore I, Schoenfeld AJ, Miller M, Kartha VK, Westcott PMK, Sánchez-Rivera FJ, Meli K, Gupta M, Bronson RT, Riely GJ, Rekhtman N, Rudin CM, Kim CF, Regev A, Buenrostro JD, Jacks T. Concepcion CP, et al. Among authors: westcott pmk. Cancer Discov. 2022 Feb;12(2):562-585. doi: 10.1158/2159-8290.CD-21-0248. Epub 2021 Sep 24. Cancer Discov. 2022. PMID: 34561242 Free PMC article.
25 results