Lichtenthaler SF - Search Results

1

The case for low-level BACE1 inhibition for the prevention of Alzheimer disease.

McDade E, Voytyuk I, Aisen P, Bateman RJ, Carrillo MC, De Strooper B, Haass C, Reiman EM, Sperling R, Tariot PN, Yan R, Masters CL, Vassar R, Lichtenthaler SF. McDade E, et al. Among authors: lichtenthaler sf. Nat Rev Neurol. 2021 Nov;17(11):703-714. doi: 10.1038/s41582-021-00545-1. Epub 2021 Sep 21. Nat Rev Neurol. 2021. PMID: 34548654 Review.

2

Mutations in the transmembrane domain of APP altering gamma-secretase specificity.

Lichtenthaler SF, Ida N, Multhaup G, Masters CL, Beyreuther K. Lichtenthaler SF, et al. Biochemistry. 1997 Dec 9;36(49):15396-403. doi: 10.1021/bi971071m. Biochemistry. 1997. PMID: 9398269

3

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.

Lichtenthaler SF, Wang R, Grimm H, Uljon SN, Masters CL, Beyreuther K. Lichtenthaler SF, et al. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3053-8. doi: 10.1073/pnas.96.6.3053. Proc Natl Acad Sci U S A. 1999. PMID: 10077635 Free PMC article.

4

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

Christie G, Markwell RE, Gray CW, Smith L, Godfrey F, Mansfield F, Wadsworth H, King R, McLaughlin M, Cooper DG, Ward RV, Howlett DR, Hartmann T, Lichtenthaler SF, Beyreuther K, Underwood J, Gribble SK, Cappai R, Masters CL, Tamaoka A, Gardner RL, Rivett AJ, Karran EH, Allsop D. Christie G, et al. Among authors: lichtenthaler sf. J Neurochem. 1999 Jul;73(1):195-204. doi: 10.1046/j.1471-4159.1999.0730195.x. J Neurochem. 1999. PMID: 10386971 Free article.

5

A novel substrate for analyzing Alzheimer's disease gamma-secretase.

Lichtenthaler SF, Multhaup G, Masters CL, Beyreuther K. Lichtenthaler SF, et al. FEBS Lett. 1999 Jun 25;453(3):288-92. doi: 10.1016/s0014-5793(99)00730-9. FEBS Lett. 1999. PMID: 10405162 Free article.

6

The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.

Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K. Lichtenthaler SF, et al. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1365-70. doi: 10.1073/pnas.032395699. Epub 2002 Jan 22. Proc Natl Acad Sci U S A. 2002. PMID: 11805291 Free PMC article.

7

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted.

Grziwa B, Grimm MO, Masters CL, Beyreuther K, Hartmann T, Lichtenthaler SF. Grziwa B, et al. Among authors: lichtenthaler sf. J Biol Chem. 2003 Feb 28;278(9):6803-8. doi: 10.1074/jbc.M210047200. Epub 2002 Nov 25. J Biol Chem. 2003. PMID: 12454010 Free article.

8

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B. Lichtenthaler SF, et al. J Biol Chem. 2003 Dec 5;278(49):48713-9. doi: 10.1074/jbc.M303861200. Epub 2003 Sep 24. J Biol Chem. 2003. PMID: 14507929 Free article.

9

Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model.

Lichtenthaler SF, Haass C. Lichtenthaler SF, et al. J Clin Invest. 2004 May;113(10):1384-7. doi: 10.1172/JCI21746. J Clin Invest. 2004. PMID: 15146234 Free PMC article. Review.

10

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region.

Lammich S, Schöbel S, Zimmer AK, Lichtenthaler SF, Haass C. Lammich S, et al. Among authors: lichtenthaler sf. EMBO Rep. 2004 Jun;5(6):620-5. doi: 10.1038/sj.embor.7400166. Epub 2004 May 28. EMBO Rep. 2004. PMID: 15167888 Free PMC article.

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