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Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition.
Liu X, Verma A, Garcia G Jr, Ramage H, Lucas A, Myers RL, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. Liu X, et al. Among authors: damoiseaux r. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2113401118. doi: 10.1073/pnas.2113401118. Epub 2021 Sep 30. Proc Natl Acad Sci U S A. 2021. PMID: 34593624 Free PMC article.
A broad-spectrum antiviral targeting entry of enveloped viruses.
Wolf MC, Freiberg AN, Zhang T, Akyol-Ataman Z, Grock A, Hong PW, Li J, Watson NF, Fang AQ, Aguilar HC, Porotto M, Honko AN, Damoiseaux R, Miller JP, Woodson SE, Chantasirivisal S, Fontanes V, Negrete OA, Krogstad P, Dasgupta A, Moscona A, Hensley LE, Whelan SP, Faull KF, Holbrook MR, Jung ME, Lee B. Wolf MC, et al. Among authors: damoiseaux r. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3157-62. doi: 10.1073/pnas.0909587107. Epub 2010 Jan 28. Proc Natl Acad Sci U S A. 2010. PMID: 20133606 Free PMC article.
Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses.
Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA. Gillespie EJ, et al. Among authors: damoiseaux r. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4904-12. doi: 10.1073/pnas.1302334110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24191014 Free PMC article.
An in situ high-throughput screen identifies inhibitors of intracellular Burkholderia pseudomallei with therapeutic efficacy.
Bulterys PL, Toesca IJ, Norris MH, Maloy JP, Fitz-Gibbon ST, France B, Toffig B, Morselli M, Somprasong N, Pellegrini M, Schweizer HP, Tuanyok A, Damoiseaux R, French CT, Miller JF. Bulterys PL, et al. Among authors: damoiseaux r. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18597-18606. doi: 10.1073/pnas.1906388116. Epub 2019 Aug 22. Proc Natl Acad Sci U S A. 2019. PMID: 31439817 Free PMC article.
The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.
Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. Bhat K, et al. Among authors: damoiseaux r. Proc Natl Acad Sci U S A. 2020 May 19;117(20):11085-11096. doi: 10.1073/pnas.1920154117. Epub 2020 May 1. Proc Natl Acad Sci U S A. 2020. PMID: 32358191 Free PMC article.
Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy.
Bicak M, Lückerath K, Kalidindi T, Phelps ME, Strand SE, Morris MJ, Radu CG, Damoiseaux R, Peltola MT, Peekhaus N, Ho A, Veach D, Malmborg Hager AC, Larson SM, Lilja H, McDevitt MR, Klein RJ, Ulmert D. Bicak M, et al. Among authors: damoiseaux r. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15172-15181. doi: 10.1073/pnas.1918744117. Epub 2020 Jun 12. Proc Natl Acad Sci U S A. 2020. PMID: 32532924 Free PMC article.
Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition.
Liu X, Verma A, Garcia G, Ramage H, Myers RL, Lucas A, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. Liu X, et al. Among authors: damoiseaux r. medRxiv [Preprint]. 2021 Jul 21:2021.02.17.21251933. doi: 10.1101/2021.02.17.21251933. medRxiv. 2021. Update in: Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2113401118. doi: 10.1073/pnas.2113401118. PMID: 33655282 Free PMC article. Updated. Preprint.
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.
Mullen PJ, Garcia G Jr, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. Mullen PJ, et al. Among authors: damoiseaux r. Nat Commun. 2021 Mar 25;12(1):1876. doi: 10.1038/s41467-021-22166-4. Nat Commun. 2021. PMID: 33767183 Free PMC article.
Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication.
Garcia G Jr, Sharma A, Ramaiah A, Sen C, Purkayastha A, Kohn DB, Parcells MS, Beck S, Kim H, Bakowski MA, Kirkpatrick MG, Riva L, Wolff KC, Han B, Yuen C, Ulmert D, Purbey PK, Scumpia P, Beutler N, Rogers TF, Chatterjee AK, Gabriel G, Bartenschlager R, Gomperts B, Svendsen CN, Betz UAK, Damoiseaux RD, Arumugaswami V. Garcia G Jr, et al. Among authors: damoiseaux rd. Cell Rep. 2021 Apr 6;35(1):108940. doi: 10.1016/j.celrep.2021.108940. Epub 2021 Mar 18. Cell Rep. 2021. PMID: 33784499 Free PMC article.
275 results