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331 results

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Page 1
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
DeSelm L, Huck B, Lan R, Neagu C, Potnick J, Xiao Y, Chen X, Jones R, Richardson TE, Heasley BH, Haxell T, Moore J, Tian H, Georgi K, Rohdich F, Sutton A, Johnson T, Mochalkin I, Jackson J, Lin J, Crowley L, Machl A, Clark A, Wilker E, Sherer B, Goutopoulos A. DeSelm L, et al. Among authors: crowley l. J Med Chem. 2021 Oct 14;64(19):14603-14619. doi: 10.1021/acs.jmedchem.1c01087. Epub 2021 Oct 1. J Med Chem. 2021. PMID: 34596404
Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.
Heinrich T, Sala-Hojman A, Ferretti R, Petersson C, Minguzzi S, Gondela A, Ramaswamy S, Bartosik A, Czauderna F, Crowley L, Wahra P, Schilke H, Böpple P, Dudek Ł, Leś M, Niedziejko P, Olech K, Pawlik H, Włoszczak Ł, Zuchowicz K, Suarez Alvarez JR, Martyka J, Sitek E, Mikulski M, Szczęśniak J, Jäckel S, Krier M, Król M, Wegener A, Gałęzowski M, Nowak M, Becker F, Herhaus C. Heinrich T, et al. Among authors: crowley l. J Med Chem. 2021 Aug 26;64(16):11904-11933. doi: 10.1021/acs.jmedchem.1c00448. Epub 2021 Aug 12. J Med Chem. 2021. PMID: 34382802
Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases.
Friese-Hamim M, Clark A, Perrin D, Crowley L, Reusch C, Bogatyrova O, Zhang H, Crandall T, Lin J, Ma J, Bachner D, Schmidt J, Schaefer M, Stroh C. Friese-Hamim M, et al. Among authors: crowley l. Lung Cancer. 2022 Jan;163:77-86. doi: 10.1016/j.lungcan.2021.11.020. Epub 2021 Dec 11. Lung Cancer. 2022. PMID: 34942492 Free article.
p70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab.
Fukuoka S, Koga Y, Yamauchi M, Koganemaru S, Yasunaga M, Shitara K, Doi T, Yoshino T, Kuronita T, Elenbaas B, Wahra P, Zhang H, Crowley L, Jenkins MH, Clark A, Kojima T. Fukuoka S, et al. Among authors: crowley l. Sci Rep. 2023 Sep 25;13(1):16017. doi: 10.1038/s41598-023-40612-9. Sci Rep. 2023. PMID: 37749105 Free PMC article.
Preclinical evidence for the effective use of TL-895, a highly selective and potent second-generation BTK inhibitor, for the treatment of B-cell malignancies.
Goodstal SM, Lin J, Crandall T, Crowley L, Bender AT, Pereira A, Soloviev M, Wesolowski JS, Iadevaia R, Schelhorn SE, Ross E, Morandi F, Ma J, Clark A. Goodstal SM, et al. Among authors: crowley l. Sci Rep. 2023 Nov 21;13(1):20412. doi: 10.1038/s41598-023-47735-z. Sci Rep. 2023. PMID: 37989777 Free PMC article.
The genome sequence of the Broom moth, Ceramica pisi Linnaeus, 1758.
Griffiths A, Wawman DC, Crowley LM; University of Oxford and Wytham Woods Genome Acquisition Lab; Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team; Wellcome Sanger Institute Scientific Operations: Sequencing Operations; Wellcome Sanger Institute Tree of Life Core Informatics team; Tree of Life Core Informatics collective; Darwin Tree of Life Consortium. Griffiths A, et al. Among authors: crowley lm. Wellcome Open Res. 2024 Sep 20;9:539. doi: 10.12688/wellcomeopenres.23050.1. eCollection 2024. Wellcome Open Res. 2024. PMID: 39554249 Free PMC article.
The genome sequence of the yellow mealworm beetle, Tenebrio molitor Linnaeus, 1758.
Mann D, Crowley LM, Merino Recalde N; University of Oxford and Wytham Woods Genome Acquisition Lab; Darwin Tree of Life Barcoding collective; Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team; Wellcome Sanger Institute Scientific Operations: Sequencing Operations; Wellcome Sanger Institute Tree of Life Core Informatics team; Tree of Life Core Informatics collective; Darwin Tree of Life Consortium. Mann D, et al. Among authors: crowley lm. Wellcome Open Res. 2024 Aug 12;9:459. doi: 10.12688/wellcomeopenres.22863.1. eCollection 2024. Wellcome Open Res. 2024. PMID: 39540103 Free PMC article.
The genome sequence of the planthopper, Conomelus anceps (Germar, 1821).
Moran S, Griffiths A, Crowley LM; University of Oxford and Wytham Woods Genome Acquisition Lab; Darwin Tree of Life Barcoding collective; Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team; Wellcome Sanger Institute Scientific Operations: Sequencing Operations; Wellcome Sanger Institute Tree of Life Core Informatics team; Tree of Life Core Informatics collective; Darwin Tree of Life Consortium. Moran S, et al. Among authors: crowley lm. Wellcome Open Res. 2024 Oct 17;9:605. doi: 10.12688/wellcomeopenres.23104.1. eCollection 2024. Wellcome Open Res. 2024. PMID: 39534535 Free PMC article.
The genome sequence of the Pale November moth, Epirrita christyi (Allen, 1906).
Boyes D, Crowley LM, Boyes C; University of Oxford and Wytham Woods Genome Acquisition Lab; Darwin Tree of Life Barcoding collective; Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team; Wellcome Sanger Institute Scientific Operations: Sequencing Operations; Wellcome Sanger Institute Tree of Life Core Informatics team; Tree of Life Core Informatics collective; Darwin Tree of Life Consortium. Boyes D, et al. Among authors: crowley lm. Wellcome Open Res. 2024 Sep 20;9:540. doi: 10.12688/wellcomeopenres.23060.1. eCollection 2024. Wellcome Open Res. 2024. PMID: 39526196 Free PMC article.
331 results