Iyer MR - Search Results

1

Peripheral Hybrid CB₁R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis.

Zawatsky CN, Park JK, Abdalla J, Kunos G, Iyer MR, Cinar R. Zawatsky CN, et al. Among authors: iyer mr. Front Endocrinol (Lausanne). 2021 Sep 28;12:744857. doi: 10.3389/fendo.2021.744857. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34650521 Free PMC article.

2

Structural Basis of Species-Dependent Differential Affinity of 6-Alkoxy-5-Aryl-3-Pyridinecarboxamide Cannabinoid-1 Receptor Antagonists.

Iyer MR, Cinar R, Liu J, Godlewski G, Szanda G, Puhl H, Ikeda SR, Deschamps J, Lee YS, Steinbach PJ, Kunos G. Iyer MR, et al. Mol Pharmacol. 2015 Aug;88(2):238-44. doi: 10.1124/mol.115.098541. Epub 2015 May 26. Mol Pharmacol. 2015. PMID: 26013543 Free PMC article.

3

Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis.

Cinar R, Iyer MR, Liu Z, Cao Z, Jourdan T, Erdelyi K, Godlewski G, Szanda G, Liu J, Park JK, Mukhopadhyay B, Rosenberg AZ, Liow JS, Lorenz RG, Pacher P, Innis RB, Kunos G. Cinar R, et al. Among authors: iyer mr. JCI Insight. 2016 Jul 21;1(11):e87336. doi: 10.1172/jci.insight.87336. JCI Insight. 2016. PMID: 27525312 Free PMC article.

4

Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB₁R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis.

Iyer MR, Cinar R, Katz A, Gao M, Erdelyi K, Jourdan T, Coffey NJ, Pacher P, Kunos G. Iyer MR, et al. J Med Chem. 2017 Feb 9;60(3):1126-1141. doi: 10.1021/acs.jmedchem.6b01504. Epub 2017 Jan 27. J Med Chem. 2017. PMID: 28085283

5

Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis.

Cinar R, Gochuico BR, Iyer MR, Jourdan T, Yokoyama T, Park JK, Coffey NJ, Pri-Chen H, Szanda G, Liu Z, Mackie K, Gahl WA, Kunos G. Cinar R, et al. Among authors: iyer mr. JCI Insight. 2017 Apr 20;2(8):e92281. doi: 10.1172/jci.insight.92281. eCollection 2017 Apr 20. JCI Insight. 2017. PMID: 28422760 Free PMC article.

6

Synthesis of S-2-((S)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-(methyl-d₃ )butanamide-d₅ , octadeuterated JD5037.

Iyer MR, Cinar R, Coffey NJ, Chorvat RJ, Kunos G. Iyer MR, et al. J Labelled Comp Radiopharm. 2017 Aug;60(10):460-465. doi: 10.1002/jlcr.3521. Epub 2017 Aug 2. J Labelled Comp Radiopharm. 2017. PMID: 28545167 Free PMC article.

7

Synthesis of ¹³ C₆ -labeled, dual-target inhibitor of cannabinoid-1 receptor (CB₁ R) and inducible nitric oxide synthase (iNOS).

Iyer MR, Cinar R, Coffey NJ, Kunos G. Iyer MR, et al. J Labelled Comp Radiopharm. 2018 May 23. doi: 10.1002/jlcr.3639. Online ahead of print. J Labelled Comp Radiopharm. 2018. PMID: 29790591

8

Crystal Structure of the Human Cannabinoid Receptor CB2.

Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, Wang J, Wu M, Katritch V, Zhao S, Kunos G, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Li X, et al. Among authors: iyer mr. Cell. 2019 Jan 24;176(3):459-467.e13. doi: 10.1016/j.cell.2018.12.011. Epub 2019 Jan 10. Cell. 2019. PMID: 30639103 Free PMC article.

9

Targeting Peripheral CB₁ Receptors Reduces Ethanol Intake via a Gut-Brain Axis.

Godlewski G, Cinar R, Coffey NJ, Liu J, Jourdan T, Mukhopadhyay B, Chedester L, Liu Z, Osei-Hyiaman D, Iyer MR, Park JK, Smith RG, Iwakura H, Kunos G. Godlewski G, et al. Among authors: iyer mr. Cell Metab. 2019 Jun 4;29(6):1320-1333.e8. doi: 10.1016/j.cmet.2019.04.012. Epub 2019 May 16. Cell Metab. 2019. PMID: 31105045 Free PMC article.

10

Dual inhibition of cannabinoid CB₁ receptor and inducible NOS attenuates obesity-induced chronic kidney disease.

Udi S, Hinden L, Ahmad M, Drori A, Iyer MR, Cinar R, Herman-Edelstein M, Tam J. Udi S, et al. Among authors: iyer mr. Br J Pharmacol. 2020 Jan;177(1):110-127. doi: 10.1111/bph.14849. Epub 2019 Dec 27. Br J Pharmacol. 2020. PMID: 31454063 Free PMC article.

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