Chen Q - Search Results

1

Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment.

Li C, Yang X, Luo Y, Liu H, Zhong X, Zhou X, Zeng T, Tao L, Zhou Y, Gou K, Yang X, Liu X, Chen Q, Zhao Y, Luo Y. Li C, et al. Among authors: chen q. J Med Chem. 2021 Dec 23;64(24):18175-18192. doi: 10.1021/acs.jmedchem.1c01711. Epub 2021 Dec 14. J Med Chem. 2021. PMID: 34905371

2

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations.

Ji S, Ma S, Wang WJ, Huang SZ, Wang TQ, Xiang R, Hu YG, Chen Q, Li LL, Yang SY. Ji S, et al. Among authors: chen q. Chem Biol Drug Des. 2017 Apr;89(4):585-598. doi: 10.1111/cbdd.12881. Epub 2016 Nov 10. Chem Biol Drug Des. 2017. PMID: 27714957

3

((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.

Liu S, Jing L, Yu ZJ, Wu C, Zheng Y, Zhang E, Chen Q, Yu Y, Guo L, Wu Y, Li GB. Liu S, et al. Among authors: chen q. Eur J Med Chem. 2018 Feb 10;145:649-660. doi: 10.1016/j.ejmech.2018.01.032. Epub 2018 Jan 11. Eur J Med Chem. 2018. PMID: 29353720

4

X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.

Yang LL, Wang HL, Zhong L, Yuan C, Liu SY, Yu ZJ, Liu S, Yan YH, Wu C, Wang Y, Wang Z, Yu Y, Chen Q, Li GB. Yang LL, et al. Among authors: chen q. Eur J Med Chem. 2018 Jul 15;155:806-823. doi: 10.1016/j.ejmech.2018.06.041. Epub 2018 Jun 19. Eur J Med Chem. 2018. PMID: 29957526

5

Discovery of a Prenylated Flavonol Derivative as a Pin1 Inhibitor to Suppress Hepatocellular Carcinoma by Modulating MicroRNA Biogenesis.

Zheng Y, Pu W, Li J, Shen X, Zhou Q, Fan X, Yang SY, Yu Y, Chen Q, Wang C, Wu X, Peng Y. Zheng Y, et al. Among authors: chen q. Chem Asian J. 2019 Jan 4;14(1):130-134. doi: 10.1002/asia.201801461. Epub 2018 Nov 26. Chem Asian J. 2019. PMID: 30474357

6

A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.

Zeng T, Zuo Z, Luo Y, Zhao Y, Yu Y, Chen Q. Zeng T, et al. Among authors: chen q. FEBS Open Bio. 2019 Aug;9(8):1348-1354. doi: 10.1002/2211-5463.12658. Epub 2019 May 29. FEBS Open Bio. 2019. PMID: 31087527 Free PMC article.

7

Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-β-lactamases.

Wang YL, Liu S, Yu ZJ, Lei Y, Huang MY, Yan YH, Ma Q, Zheng Y, Deng H, Sun Y, Wu C, Yu Y, Chen Q, Wang Z, Wu Y, Li GB. Wang YL, et al. Among authors: chen q. J Med Chem. 2019 Aug 8;62(15):7160-7184. doi: 10.1021/acs.jmedchem.9b00735. Epub 2019 Jul 17. J Med Chem. 2019. PMID: 31269398

8

Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.

Zuo Z, Liu X, Qian X, Zeng T, Sang N, Liu H, Zhou Y, Tao L, Zhou X, Su N, Yu Y, Chen Q, Luo Y, Zhao Y. Zuo Z, et al. Among authors: chen q. J Med Chem. 2020 Jul 23;63(14):7633-7652. doi: 10.1021/acs.jmedchem.0c00512. Epub 2020 Jul 1. J Med Chem. 2020. PMID: 32496056

9

Correction to "Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production".

Zuo Z, Liu X, Qian X, Zeng T, Sang N, Liu H, Zhou Y, Tao L, Zhou X, Su N, Yu Y, Chen Q, Luo Y, Zhao Y. Zuo Z, et al. Among authors: chen q. J Med Chem. 2020 Sep 24;63(18):10532. doi: 10.1021/acs.jmedchem.0c01455. Epub 2020 Sep 14. J Med Chem. 2020. PMID: 32924476 No abstract available.

10

Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D.

Fang Z, Liu Y, Zhang R, Chen Q, Wang T, Yang W, Fan Y, Yu C, Xiang R, Yang S. Fang Z, et al. Among authors: chen q. Eur J Med Chem. 2021 Nov 5;223:113662. doi: 10.1016/j.ejmech.2021.113662. Epub 2021 Jun 26. Eur J Med Chem. 2021. PMID: 34237635

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