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Prednisolone reduces the interferon response to AAV in cynomolgus macaques and may increase liver gene expression.
Wang L, Warzecha CC, Kistner A, Chichester JA, Bell P, Buza EL, He Z, Pampena MB, Couthouis J, Sethi S, McKeever K, Betts MR, Kakkis E, Wilson JM, Wadsworth S, Sullivan BA. Wang L, et al. Among authors: wadsworth s. Mol Ther Methods Clin Dev. 2022 Jan 19;24:292-305. doi: 10.1016/j.omtm.2022.01.007. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2022. PMID: 35211641 Free PMC article.
AAV2 vector harboring a liver-restricted promoter facilitates sustained expression of therapeutic levels of alpha-galactosidase A and the induction of immune tolerance in Fabry mice.
Ziegler RJ, Lonning SM, Armentano D, Li C, Souza DW, Cherry M, Ford C, Barbon CM, Desnick RJ, Gao G, Wilson JM, Peluso R, Godwin S, Carter BJ, Gregory RJ, Wadsworth SC, Cheng SH. Ziegler RJ, et al. Among authors: wadsworth sc. Mol Ther. 2004 Feb;9(2):231-40. doi: 10.1016/j.ymthe.2003.11.015. Mol Ther. 2004. PMID: 14759807 Free article.
Aurintricarboxylic acid increases yield of HSV-1 vectors.
Pechan P, Ardinger J, Ketavarapu J, Rubin H, Wadsworth SC, Scaria A. Pechan P, et al. Mol Ther Methods Clin Dev. 2014 Feb 19;1:6. doi: 10.1038/mtm.2013.6. eCollection 2014. Mol Ther Methods Clin Dev. 2014. PMID: 26015945 Free PMC article.
Adeno-Associated Virus Gene Therapy for Liver Disease.
Kattenhorn LM, Tipper CH, Stoica L, Geraghty DS, Wright TL, Clark KR, Wadsworth SC. Kattenhorn LM, et al. Among authors: wadsworth sc. Hum Gene Ther. 2016 Dec;27(12):947-961. doi: 10.1089/hum.2016.160. Hum Gene Ther. 2016. PMID: 27897038 Free PMC article. Review.
300 results