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Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite-binding site.
Sanders MJ, Ratinaud Y, Neopane K, Bonhoure N, Day EA, Ciclet O, Lassueur S, Naranjo Pinta M, Deak M, Brinon B, Christen S, Steinberg GR, Barron D, Sakamoto K. Sanders MJ, et al. Among authors: naranjo pinta m. J Biol Chem. 2022 May;298(5):101852. doi: 10.1016/j.jbc.2022.101852. Epub 2022 Mar 21. J Biol Chem. 2022. PMID: 35331736 Free PMC article.
Standardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts.
Coulerie P, Ratinaud Y, Moco S, Merminod L, Naranjo Pinta M, Boccard J, Bultot L, Deak M, Sakamoto K, Queiroz EF, Wolfender JL, Barron D. Coulerie P, et al. Among authors: naranjo pinta m. J Nat Prod. 2016 Nov 23;79(11):2856-2864. doi: 10.1021/acs.jnatprod.6b00628. Epub 2016 Oct 28. J Nat Prod. 2016. PMID: 27792327