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Differential responses to immune checkpoint inhibitor dictated by pre-existing differential immune profiles in squamous cell carcinomas caused by same initial oncogenic drivers.
Chen SMY, Popolizio V, Woolaver RA, Ge H, Krinsky AL, John J, Danis E, Ke Y, Kramer Y, Bian L, Nicklawsky AG, Gao D, Liu S, Chen Z, Wang XJ, Wang JH. Chen SMY, et al. Among authors: krinsky al. J Exp Clin Cancer Res. 2022 Apr 2;41(1):123. doi: 10.1186/s13046-022-02337-x. J Exp Clin Cancer Res. 2022. PMID: 35366939 Free PMC article.
Tumor immune microenvironment in head and neck cancers.
Chen SMY, Krinsky AL, Woolaver RA, Wang X, Chen Z, Wang JH. Chen SMY, et al. Among authors: krinsky al. Mol Carcinog. 2020 Jul;59(7):766-774. doi: 10.1002/mc.23162. Epub 2020 Feb 3. Mol Carcinog. 2020. PMID: 32017286 Free PMC article. Review.
Differences in TCR repertoire and T cell activation underlie the divergent outcomes of antitumor immune responses in tumor-eradicating versus tumor-progressing hosts.
Woolaver RA, Wang X, Krinsky AL, Waschke BC, Chen SMY, Popolizio V, Nicklawsky AG, Gao D, Chen Z, Jimeno A, Wang XJ, Wang JH. Woolaver RA, et al. Among authors: krinsky al. J Immunother Cancer. 2021 Jan;9(1):e001615. doi: 10.1136/jitc-2020-001615. J Immunother Cancer. 2021. PMID: 33414263 Free PMC article.
Divergent outcomes of anti-PD-L1 treatment coupled with host-intrinsic differences in TCR repertoire and distinct T cell activation states in responding versus non-responding tumors.
John J, Woolaver RA, Popolizio V, Chen SMY, Ge H, Krinsky AL, Vashisht M, Kramer Y, Chen Z, Wang JH. John J, et al. Among authors: krinsky al. Front Immunol. 2022 Oct 18;13:992630. doi: 10.3389/fimmu.2022.992630. eCollection 2022. Front Immunol. 2022. PMID: 36330507 Free PMC article.