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Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function.
Veatch JR, Lee SM, Shasha C, Singhi N, Szeto JL, Moshiri AS, Kim TS, Smythe K, Kong P, Fitzgibbon M, Jesernig B, Bhatia S, Tykodi SS, Hall ET, Byrd DR, Thompson JA, Pillarisetty VG, Duhen T, McGarry Houghton A, Newell E, Gottardo R, Riddell SR. Veatch JR, et al. Among authors: gottardo r. Cancer Cell. 2022 Apr 11;40(4):393-409.e9. doi: 10.1016/j.ccell.2022.03.006. Cancer Cell. 2022. PMID: 35413271 Free PMC article.
Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function.
Salter AI, Ivey RG, Kennedy JJ, Voillet V, Rajan A, Alderman EJ, Voytovich UJ, Lin C, Sommermeyer D, Liu L, Whiteaker JR, Gottardo R, Paulovich AG, Riddell SR. Salter AI, et al. Among authors: gottardo r. Sci Signal. 2018 Aug 21;11(544):eaat6753. doi: 10.1126/scisignal.aat6753. Sci Signal. 2018. PMID: 30131370 Free PMC article.
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA.
Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG. Paulson KG, et al. Among authors: gottardo r. Nat Commun. 2018 Sep 24;9(1):3868. doi: 10.1038/s41467-018-06300-3. Nat Commun. 2018. PMID: 30250229 Free PMC article.
Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy.
Sheih A, Voillet V, Hanafi LA, DeBerg HA, Yajima M, Hawkins R, Gersuk V, Riddell SR, Maloney DG, Wohlfahrt ME, Pande D, Enstrom MR, Kiem HP, Adair JE, Gottardo R, Linsley PS, Turtle CJ. Sheih A, et al. Among authors: gottardo r. Nat Commun. 2020 Jan 10;11(1):219. doi: 10.1038/s41467-019-13880-1. Nat Commun. 2020. PMID: 31924795 Free PMC article. Clinical Trial.
PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy.
Simon S, Voillet V, Vignard V, Wu Z, Dabrowski C, Jouand N, Beauvais T, Khammari A, Braudeau C, Josien R, Adotevi O, Laheurte C, Aubin F, Nardin C, Rulli S, Gottardo R, Ramchurren N, Cheever M, Fling SP, Church CD, Nghiem P, Dreno B, Riddell SR, Labarriere N. Simon S, et al. Among authors: gottardo r. J Immunother Cancer. 2020 Nov;8(2):e001631. doi: 10.1136/jitc-2020-001631. J Immunother Cancer. 2020. PMID: 33188038 Free PMC article.
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.
Srivastava S, Furlan SN, Jaeger-Ruckstuhl CA, Sarvothama M, Berger C, Smythe KS, Garrison SM, Specht JM, Lee SM, Amezquita RA, Voillet V, Muhunthan V, Yechan-Gunja S, Pillai SPS, Rader C, Houghton AM, Pierce RH, Gottardo R, Maloney DG, Riddell SR. Srivastava S, et al. Among authors: gottardo r. Cancer Cell. 2021 Feb 8;39(2):193-208.e10. doi: 10.1016/j.ccell.2020.11.005. Epub 2020 Dec 24. Cancer Cell. 2021. PMID: 33357452 Free PMC article.
The human memory T cell compartment changes across tissues of the female reproductive tract.
Woodward Davis AS, Vick SC, Pattacini L, Voillet V, Hughes SM, Lentz GM, Kirby AC, Fialkow MF, Gottardo R, Hladik F, Lund JM, Prlic M. Woodward Davis AS, et al. Among authors: gottardo r. Mucosal Immunol. 2021 Jul;14(4):862-872. doi: 10.1038/s41385-021-00406-6. Epub 2021 May 5. Mucosal Immunol. 2021. PMID: 33953338 Free PMC article.
246 results