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Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures.
Hammoud MK, Dietze R, Pesek J, Finkernagel F, Unger A, Bieringer T, Nist A, Stiewe T, Bhagwat AM, Nockher WA, Reinartz S, Müller-Brüsselbach S, Graumann J, Müller R. Hammoud MK, et al. Among authors: reinartz s. Mol Oncol. 2022 Sep;16(17):3146-3166. doi: 10.1002/1878-0261.13221. Epub 2022 May 4. Mol Oncol. 2022. PMID: 35451191 Free PMC article.
Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion.
Adhikary T, Brandt DT, Kaddatz K, Stockert J, Naruhn S, Meissner W, Finkernagel F, Obert J, Lieber S, Scharfe M, Jarek M, Toth PM, Scheer F, Diederich WE, Reinartz S, Grosse R, Müller-Brüsselbach S, Müller R. Adhikary T, et al. Among authors: reinartz s. Oncogene. 2013 Oct 31;32(44):5241-52. doi: 10.1038/onc.2012.549. Epub 2012 Dec 3. Oncogene. 2013. PMID: 23208498 Free PMC article.
The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state.
Adhikary T, Wortmann A, Schumann T, Finkernagel F, Lieber S, Roth K, Toth PM, Diederich WE, Nist A, Stiewe T, Kleinesudeik L, Reinartz S, Müller-Brüsselbach S, Müller R. Adhikary T, et al. Among authors: reinartz s. Nucleic Acids Res. 2015 May 26;43(10):5033-51. doi: 10.1093/nar/gkv331. Epub 2015 Apr 30. Nucleic Acids Res. 2015. PMID: 25934804 Free PMC article.
Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment.
Schumann T, Adhikary T, Wortmann A, Finkernagel F, Lieber S, Schnitzer E, Legrand N, Schober Y, Nockher WA, Toth PM, Diederich WE, Nist A, Stiewe T, Wagner U, Reinartz S, Müller-Brüsselbach S, Müller R. Schumann T, et al. Among authors: reinartz s. Oncotarget. 2015 May 30;6(15):13416-33. doi: 10.18632/oncotarget.3826. Oncotarget. 2015. PMID: 25968567 Free PMC article.
The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization.
Finkernagel F, Reinartz S, Lieber S, Adhikary T, Wortmann A, Hoffmann N, Bieringer T, Nist A, Stiewe T, Jansen JM, Wagner U, Müller-Brüsselbach S, Müller R. Finkernagel F, et al. Among authors: reinartz s. Oncotarget. 2016 Nov 15;7(46):75339-75352. doi: 10.18632/oncotarget.12180. Oncotarget. 2016. PMID: 27659538 Free PMC article.
The Unique Molecular and Cellular Microenvironment of Ovarian Cancer.
Worzfeld T, Pogge von Strandmann E, Huber M, Adhikary T, Wagner U, Reinartz S, Müller R. Worzfeld T, et al. Among authors: reinartz s. Front Oncol. 2017 Feb 22;7:24. doi: 10.3389/fonc.2017.00024. eCollection 2017. Front Oncol. 2017. PMID: 28275576 Free PMC article. Review.
151 results