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Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging.
Liu Z, Ji Q, Ren J, Yan P, Wu Z, Wang S, Sun L, Wang Z, Li J, Sun G, Liang C, Sun R, Jiang X, Hu J, Ding Y, Wang Q, Bi S, Wei G, Cao G, Zhao G, Wang H, Zhou Q, Belmonte JCI, Qu J, Zhang W, Liu GH. Liu Z, et al. Among authors: belmonte jci. Dev Cell. 2022 Jun 6;57(11):1347-1368.e12. doi: 10.1016/j.devcel.2022.05.004. Epub 2022 May 24. Dev Cell. 2022. PMID: 35613614 Free article.
Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs.
Liu GH, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla RD, Goebl A, Aizawa E, Kim NY, Kim J, Dubova I, Li Y, Ren R, Benner C, Del Sol A, Bueren J, Trujillo JP, Surralles J, Cappelli E, Dufour C, Esteban CR, Belmonte JCI. Liu GH, et al. Among authors: belmonte jci. Nat Commun. 2014 Jul 7;5:4330. doi: 10.1038/ncomms5330. Nat Commun. 2014. PMID: 24999918 Free PMC article.
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC. Zhang W, et al. Science. 2015 Jun 5;348(6239):1160-3. doi: 10.1126/science.aaa1356. Epub 2015 Apr 30. Science. 2015. PMID: 25931448 Free PMC article.
Anti-Aging Strategies Based on Cellular Reprogramming.
Ocampo A, Reddy P, Belmonte JCI. Ocampo A, et al. Among authors: belmonte jci. Trends Mol Med. 2016 Aug;22(8):725-738. doi: 10.1016/j.molmed.2016.06.005. Epub 2016 Jul 14. Trends Mol Med. 2016. PMID: 27426043 Review.
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration.
Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nuñez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. Suzuki K, et al. Nature. 2016 Dec 1;540(7631):144-149. doi: 10.1038/nature20565. Epub 2016 Nov 16. Nature. 2016. PMID: 27851729 Free PMC article.
LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death.
Yoon JH, Mo JS, Kim MY, Ann EJ, Ahn JS, Jo EH, Lee HJ, Lee YC, Seol W, Yarmoluk SM, Gasser T, Kahle PJ, Liu GH, Belmonte JCI, Park HS. Yoon JH, et al. Among authors: belmonte jci. Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2356-2368. doi: 10.1016/j.bbamcr.2017.09.001. Epub 2017 Sep 6. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28888991 Free article.
94 results