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Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.
Okorom AV, Camacho-Hernandez GA, Salomon K, Lee KH, Ku TC, Cao J, Won SJ, Friedman J, Lam J, Paule J, Rais R, Klein B, Xi ZX, Shi L, Loland CJ, Newman AH. Okorom AV, et al. Among authors: loland cj. J Med Chem. 2024 Jan 11;67(1):709-727. doi: 10.1021/acs.jmedchem.3c02037. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117239
Persistent binding at dopamine transporters determines sustained psychostimulant effects.
Niello M, Sideromenos S, Gradisch R, O Shea R, Schwazer J, Maier J, Kastner N, Sandtner W, Jäntsch K, Lupica CR, Hoffman AF, Lubec G, Loland CJ, Stockner T, Pollak DD, Baumann MH, Sitte HH. Niello M, et al. Among authors: loland cj. Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2114204120. doi: 10.1073/pnas.2114204120. Epub 2023 Feb 2. Proc Natl Acad Sci U S A. 2023. PMID: 36730201 Free PMC article.
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins.
Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Chandra R, Goren MA, Kruse AC, Nurva S, Loland CJ, Pierre Y, Drew D, Popot JL, Picot D, Fox BG, Guan L, Gether U, Byrne B, Kobilka B, Gellman SH. Chae PS, et al. Among authors: loland cj. Nat Methods. 2010 Dec;7(12):1003-8. doi: 10.1038/nmeth.1526. Epub 2010 Oct 31. Nat Methods. 2010. PMID: 21037590 Free PMC article.
Tandem facial amphiphiles for membrane protein stabilization.
Chae PS, Gotfryd K, Pacyna J, Miercke LJ, Rasmussen SG, Robbins RA, Rana RR, Loland CJ, Kobilka B, Stroud R, Byrne B, Gether U, Gellman SH. Chae PS, et al. Among authors: loland cj. J Am Chem Soc. 2010 Dec 1;132(47):16750-2. doi: 10.1021/ja1072959. Epub 2010 Nov 4. J Am Chem Soc. 2010. PMID: 21049926 Free PMC article.
A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins.
Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH. Chae PS, et al. Among authors: loland cj. Chemistry. 2012 Jul 27;18(31):9485-90. doi: 10.1002/chem.201200069. Epub 2012 Jun 22. Chemistry. 2012. PMID: 22730191 Free PMC article. No abstract available.
Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study.
Chae PS, Rana RR, Gotfryd K, Rasmussen SG, Kruse AC, Cho KH, Capaldi S, Carlsson E, Kobilka B, Loland CJ, Gether U, Banerjee S, Byrne B, Lee JK, Gellman SH. Chae PS, et al. Among authors: loland cj. Chem Commun (Camb). 2013 Mar 21;49(23):2287-9. doi: 10.1039/c2cc36844g. Chem Commun (Camb). 2013. PMID: 23165475 Free PMC article.
Novel tripod amphiphiles for membrane protein analysis.
Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SG, Bae HE, Chandra R, Gether U, Guan L, Kobilka BK, Loland CJ, Byrne B, Gellman SH. Chae PS, et al. Among authors: loland cj. Chemistry. 2013 Nov 11;19(46):15645-51. doi: 10.1002/chem.201301423. Epub 2013 Oct 2. Chemistry. 2013. PMID: 24123610 Free PMC article.
Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study.
Cho KH, Husri M, Amin A, Gotfryd K, Lee HJ, Go J, Kim JW, Loland CJ, Guan L, Byrne B, Chae PS. Cho KH, et al. Among authors: loland cj. Analyst. 2015 May 7;140(9):3157-63. doi: 10.1039/c5an00240k. Epub 2015 Mar 27. Analyst. 2015. PMID: 25813698 Free PMC article.
114 results