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Page 1
Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.
Oudelaar AM, Davies JOJ, Hanssen LLP, Telenius JM, Schwessinger R, Liu Y, Brown JM, Downes DJ, Chiariello AM, Bianco S, Nicodemi M, Buckle VJ, Dekker J, Higgs DR, Hughes JR. Oudelaar AM, et al. Among authors: schwessinger r. Nat Genet. 2018 Dec;50(12):1744-1751. doi: 10.1038/s41588-018-0253-2. Epub 2018 Oct 29. Nat Genet. 2018. PMID: 30374068 Free PMC article.
Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities.
Scott C, Downes DJ, Brown JM, Beagrie R, Olijnik AA, Gosden M, Schwessinger R, Fisher CA, Rose A, Ferguson DJP, Johnson E, Hill QA, Okoli S, Renella R, Ryan K, Brand M, Hughes J, Roy NBA, Higgs DR, Babbs C, Buckle VJ. Scott C, et al. Among authors: schwessinger r. Haematologica. 2021 Nov 1;106(11):2960-2970. doi: 10.3324/haematol.2020.260158. Haematologica. 2021. PMID: 33121234 Free PMC article.
High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.
Downes DJ, Beagrie RA, Gosden ME, Telenius J, Carpenter SJ, Nussbaum L, De Ornellas S, Sergeant M, Eijsbouts CQ, Schwessinger R, Kerry J, Roberts N, Shivalingam A, El-Sagheer A, Oudelaar AM, Brown T, Buckle VJ, Davies JOJ, Hughes JR. Downes DJ, et al. Among authors: schwessinger r. Nat Commun. 2021 Jan 22;12(1):531. doi: 10.1038/s41467-020-20809-6. Nat Commun. 2021. PMID: 33483495 Free PMC article.
Defining genome architecture at base-pair resolution.
Hua P, Badat M, Hanssen LLP, Hentges LD, Crump N, Downes DJ, Jeziorska DM, Oudelaar AM, Schwessinger R, Taylor S, Milne TA, Hughes JR, Higgs DR, Davies JOJ. Hua P, et al. Among authors: schwessinger r. Nature. 2021 Jul;595(7865):125-129. doi: 10.1038/s41586-021-03639-4. Epub 2021 Jun 9. Nature. 2021. PMID: 34108683
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus.
Downes DJ, Cross AR, Hua P, Roberts N, Schwessinger R, Cutler AJ, Munis AM, Brown J, Mielczarek O, de Andrea CE, Melero I; COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium; Gill DR, Hyde SC, Knight JC, Todd JA, Sansom SN, Issa F, Davies JOJ, Hughes JR. Downes DJ, et al. Among authors: schwessinger r. Nat Genet. 2021 Nov;53(11):1606-1615. doi: 10.1038/s41588-021-00955-3. Epub 2021 Nov 4. Nat Genet. 2021. PMID: 34737427 Free PMC article.
Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development.
Owens DDG, Anselmi G, Oudelaar AM, Downes DJ, Cavallo A, Harman JR, Schwessinger R, Bucakci A, Greder L, de Ornellas S, Jeziorska D, Telenius J, Hughes JR, de Bruijn MFTR. Owens DDG, et al. Among authors: schwessinger r. Nat Commun. 2022 Feb 9;13(1):773. doi: 10.1038/s41467-022-28376-8. Nat Commun. 2022. PMID: 35140205 Free PMC article.
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