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Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo.
de Boer C, Armstrong Z, Lit VAJ, Barash U, Ruijgrok G, Boyango I, Weitzenberg MM, Schröder SP, Sarris AJC, Meeuwenoord NJ, Bule P, Kayal Y, Ilan N, Codée JDC, Vlodavsky I, Overkleeft HS, Davies GJ, Wu L. de Boer C, et al. Among authors: schroder sp. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2203167119. doi: 10.1073/pnas.2203167119. Epub 2022 Jul 26. Proc Natl Acad Sci U S A. 2022. PMID: 35881786 Free PMC article.
From covalent glycosidase inhibitors to activity-based glycosidase probes.
Willems LI, Jiang J, Li KY, Witte MD, Kallemeijn WW, Beenakker TJ, Schröder SP, Aerts JM, van der Marel GA, Codée JD, Overkleeft HS. Willems LI, et al. Among authors: schroder sp. Chemistry. 2014 Aug 25;20(35):10864-72. doi: 10.1002/chem.201404014. Epub 2014 Aug 5. Chemistry. 2014. PMID: 25100671
Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines.
Schröder SP, van de Sande JW, Kallemeijn WW, Kuo CL, Artola M, van Rooden EJ, Jiang J, Beenakker TJM, Florea BI, Offen WA, Davies GJ, Minnaard AJ, Aerts JMFG, Codée JDC, van der Marel GA, Overkleeft HS. Schröder SP, et al. Chem Commun (Camb). 2017 Nov 21;53(93):12528-12531. doi: 10.1039/c7cc07730k. Chem Commun (Camb). 2017. PMID: 29116266
Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor.
Schröder SP, Wu L, Artola M, Hansen T, Offen WA, Ferraz MJ, Li KY, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS. Schröder SP, et al. J Am Chem Soc. 2018 Apr 18;140(15):5045-5048. doi: 10.1021/jacs.8b02399. Epub 2018 Apr 4. J Am Chem Soc. 2018. PMID: 29601200 Free PMC article.
Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes.
Schröder SP, de Boer C, McGregor NGS, Rowland RJ, Moroz O, Blagova E, Reijngoud J, Arentshorst M, Osborn D, Morant MD, Abbate E, Stringer MA, Krogh KBRM, Raich L, Rovira C, Berrin JG, van Wezel GP, Ram AFJ, Florea BI, van der Marel GA, Codée JDC, Wilson KS, Wu L, Davies GJ, Overkleeft HS. Schröder SP, et al. ACS Cent Sci. 2019 Jun 26;5(6):1067-1078. doi: 10.1021/acscentsci.9b00221. Epub 2019 May 24. ACS Cent Sci. 2019. PMID: 31263766 Free PMC article.
An overview of activity-based probes for glycosidases.
Wu L, Armstrong Z, Schröder SP, de Boer C, Artola M, Aerts JM, Overkleeft HS, Davies GJ. Wu L, et al. Among authors: schroder sp. Curr Opin Chem Biol. 2019 Dec;53:25-36. doi: 10.1016/j.cbpa.2019.05.030. Epub 2019 Aug 13. Curr Opin Chem Biol. 2019. PMID: 31419756 Review.
Direct Stereoselective Aziridination of Cyclohexenols with 3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors.
Artola M, Wouters S, Schröder SP, de Boer C, Chen Y, Petracca R, van den Nieuwendijk AMCH, Aerts JMFG, van der Marel GA, Codée JDC, Overkleeft HS. Artola M, et al. Among authors: schroder sp. European J Org Chem. 2019 Feb 14;2019(6):1397-1404. doi: 10.1002/ejoc.201801703. Epub 2019 Jan 11. European J Org Chem. 2019. PMID: 31787842 Free PMC article.
Dynamics of Ligand Binding to a Rigid Glycosidase*.
Ben Bdira F, Waudby CA, Volkov AN, Schröder SP, Ab E, Codée JDC, Overkleeft HS, Aerts JMFG, van Ingen H, Ubbink M. Ben Bdira F, et al. Among authors: schroder sp. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20508-20514. doi: 10.1002/anie.202003236. Epub 2020 Sep 3. Angew Chem Int Ed Engl. 2020. PMID: 32533782 Free PMC article.
19 results