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The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling.
Laplantine E, Chable-Bessia C, Oudin A, Swain J, Soria A, Merida P, Gourdelier M, Mestiri S, Besseghe I, Bremaud E, Neyret A, Lyonnais S, Favard C, Benaroch P, Hubert M, Schwartz O, Guerin M, Danckaert A, Del Nery E, Muriaux D, Weil R. Laplantine E, et al. Among authors: gourdelier m. iScience. 2022 Oct 21;25(10):105066. doi: 10.1016/j.isci.2022.105066. Epub 2022 Sep 3. iScience. 2022. PMID: 36093378 Free PMC article.
The multifunction Coxiella effector Vice stimulates macropinocytosis and interferes with the ESCRT machinery.
Bienvenu A, Burette M, Cantet F, Gourdelier M, Swain J, Cazevieille C, Clemente T, Sadi A, Dupont C, Le Fe M, Bonetto N, Bordignon B, Muriaux D, Gilk S, Bonazzi M, Martinez E. Bienvenu A, et al. Among authors: gourdelier m. Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2315481121. doi: 10.1073/pnas.2315481121. Epub 2024 Jun 13. Proc Natl Acad Sci U S A. 2024. PMID: 38870060