Kalel VC - Search Results

1

Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma.

Napolitano V, Softley CA, Blat A, Kalel VC, Schorpp K, Siebenmorgen T, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dubin G. Napolitano V, et al. Among authors: kalel vc. Sci Rep. 2022 Aug 29;12(1):14705. doi: 10.1038/s41598-022-18841-1. Sci Rep. 2022. PMID: 36038611 Free PMC article.

2

Molecular basis of peroxisomal biogenesis disorders caused by defects in peroxisomal matrix protein import.

Nagotu S, Kalel VC, Erdmann R, Platta HW. Nagotu S, et al. Among authors: kalel vc. Biochim Biophys Acta. 2012 Sep;1822(9):1326-36. doi: 10.1016/j.bbadis.2012.05.010. Epub 2012 May 19. Biochim Biophys Acta. 2012. PMID: 22617146 Free article. Review.

3

Identification and functional characterization of Trypanosoma brucei peroxin 16.

Kalel VC, Schliebs W, Erdmann R. Kalel VC, et al. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2326-37. doi: 10.1016/j.bbamcr.2015.05.024. Epub 2015 May 27. Biochim Biophys Acta. 2015. PMID: 26025675 Free article.

4

Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.

Dawidowski M, Emmanouilidis L, Kalel VC, Tripsianes K, Schorpp K, Hadian K, Kaiser M, Mäser P, Kolonko M, Tanghe S, Rodriguez A, Schliebs W, Erdmann R, Sattler M, Popowicz GM. Dawidowski M, et al. Among authors: kalel vc. Science. 2017 Mar 31;355(6332):1416-1420. doi: 10.1126/science.aal1807. Science. 2017. PMID: 28360328

5

Inhibitors of glycosomal protein import provide new leads against trypanosomiasis.

Kalel VC, Emmanouilidis L, Dawidowski M, Schliebs W, Sattler M, Popowicz GM, Erdmann R. Kalel VC, et al. Microb Cell. 2017 Jul 3;4(7):229-232. doi: 10.15698/mic2017.07.581. Microb Cell. 2017. PMID: 28706938 Free PMC article.

6

Functional Analyses of a Putative, Membrane-Bound, Peroxisomal Protein Import Mechanism from the Apicomplexan Protozoan Toxoplasma gondii.

Mbekeani AJ, Stanley WA, Kalel VC, Dahan N, Zalckvar E, Sheiner L, Schliebs W, Erdmann R, Pohl E, Denny PW. Mbekeani AJ, et al. Among authors: kalel vc. Genes (Basel). 2018 Aug 29;9(9):434. doi: 10.3390/genes9090434. Genes (Basel). 2018. PMID: 30158461 Free PMC article.

7

Unraveling of the Structure and Function of Peroxisomal Protein Import Machineries.

Kalel VC, Erdmann R. Kalel VC, et al. Subcell Biochem. 2018;89:299-321. doi: 10.1007/978-981-13-2233-4_13. Subcell Biochem. 2018. PMID: 30378029 Review.

8

Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development.

Kalel VC, Mäser P, Sattler M, Erdmann R, Popowicz GM. Kalel VC, et al. Curr Opin Microbiol. 2018 Dec;46:116-122. doi: 10.1016/j.mib.2018.11.003. Epub 2018 Nov 24. Curr Opin Microbiol. 2018. PMID: 30481613 Review.

9

Evolutionary divergent PEX3 is essential for glycosome biogenesis and survival of trypanosomatid parasites.

Kalel VC, Li M, Gaussmann S, Delhommel F, Schäfer AB, Tippler B, Jung M, Maier R, Oeljeklaus S, Schliebs W, Warscheid B, Sattler M, Erdmann R. Kalel VC, et al. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118520. doi: 10.1016/j.bbamcr.2019.07.015. Epub 2019 Jul 29. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 31369765 Free article.

10

Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.

Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM. Dawidowski M, et al. Among authors: kalel vc. J Med Chem. 2020 Jan 23;63(2):847-879. doi: 10.1021/acs.jmedchem.9b01876. Epub 2020 Jan 6. J Med Chem. 2020. PMID: 31860309

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