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SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis.
McGrath ME, Xue Y, Dillen C, Oldfield L, Assad-Garcia N, Zaveri J, Singh N, Baracco L, Taylor LJ, Vashee S, Frieman MB. McGrath ME, et al. Among authors: baracco l. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2204717119. doi: 10.1073/pnas.2204717119. Epub 2022 Aug 30. Proc Natl Acad Sci U S A. 2022. PMID: 36040867 Free PMC article.
The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses.
Weston S, Baracco L, Keller C, Matthews K, McGrath ME, Logue J, Liang J, Dyall J, Holbrook MR, Hensley LE, Jahrling PB, Yu W, MacKerell AD Jr, Frieman MB. Weston S, et al. Among authors: baracco l. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30687-30698. doi: 10.1073/pnas.2012939117. Epub 2020 Nov 12. Proc Natl Acad Sci U S A. 2020. PMID: 33184176 Free PMC article.
SARS-CoV-2 Variant Spike and accessory gene mutations alter pathogenesis.
McGrath ME, Xue Y, Dillen C, Oldfield L, Assad-Garcia N, Zaveri J, Singh N, Baracco L, Taylor L, Vashee S, Frieman M. McGrath ME, et al. Among authors: baracco l. bioRxiv [Preprint]. 2022 Jun 1:2022.05.31.494211. doi: 10.1101/2022.05.31.494211. bioRxiv. 2022. Update in: Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2204717119. doi: 10.1073/pnas.2204717119. PMID: 35677080 Free PMC article. Updated. Preprint.
PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19.
Logue J, Chakraborty AR, Johnson R, Goyal G, Rodas M, Taylor LJ, Baracco L, McGrath ME, Haupt R, Furlong BA, Soong M, Prabhala P, Horvath V, Carlson KE, Weston S, Ingber DE, DePamphilis ML, Frieman MB. Logue J, et al. Among authors: baracco l. Commun Biol. 2022 Aug 12;5(1):808. doi: 10.1038/s42003-022-03766-2. Commun Biol. 2022. PMID: 35962188 Free PMC article.
Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trial.
Mallory RM, Formica N, Pfeiffer S, Wilkinson B, Marcheschi A, Albert G, McFall H, Robinson M, Plested JS, Zhu M, Cloney-Clark S, Zhou B, Chau G, Robertson A, Maciejewski S, Hammond HL, Baracco L, Logue J, Frieman MB, Smith G, Patel N, Glenn GM; Novavax 2019nCoV101 Study Group. Mallory RM, et al. Among authors: baracco l. Lancet Infect Dis. 2022 Nov;22(11):1565-1576. doi: 10.1016/S1473-3099(22)00420-0. Epub 2022 Aug 10. Lancet Infect Dis. 2022. PMID: 35963274 Free PMC article. Clinical Trial.
Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2.
Ji Y, Zhang Q, Cheng L, Ge J, Wang R, Fang M, Mucker EM, Chen P, Ma J, Zhang R, Li C, Hammond H, Baracco L, Holbrook M, Frieman M, Zhang Z, Wang X, Hooper JW, Zhang L, Zhu Q. Ji Y, et al. Among authors: baracco l. Front Immunol. 2022 Sep 14;13:980435. doi: 10.3389/fimmu.2022.980435. eCollection 2022. Front Immunol. 2022. PMID: 36189212 Free PMC article.
Diet Induced Obesity and Diabetes Enhance Mortality and Reduces Vaccine Efficacy for SARS-CoV-2.
Johnson R, Ardunay J, Hammond H, Logue J, Jackson L, Baracco L, McGrath M, Dillen C, Patel N, Smith G, Frieman M. Johnson R, et al. Among authors: baracco l. bioRxiv [Preprint]. 2023 May 5:2022.10.15.512291. doi: 10.1101/2022.10.15.512291. bioRxiv. 2023. Update in: J Virol. 2023 Nov 30;97(11):e0133623. doi: 10.1128/jvi.01336-23. PMID: 36299426 Free PMC article. Updated. Preprint.
Mucosal and Systemic Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Determined by Severity of Primary Infection.
Sajadi MM, Myers A, Logue J, Saadat S, Shokatpour N, Quinn J, Newman M, Deming M, Rikhtegaran Tehrani Z, Magder LS, Karimi M, Abbasi A, Shlyak M, Baracco L, Frieman MB, Crotty S, Harris AD. Sajadi MM, et al. Among authors: baracco l. mSphere. 2022 Dec 21;7(6):e0027922. doi: 10.1128/msphere.00279-22. Epub 2022 Nov 2. mSphere. 2022. PMID: 36321826 Free PMC article.
17 results