Airola MV - Search Results

1

Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases.

Yi JK, Xu R, Obeid LM, Hannun YA, Airola MV, Mao C. Yi JK, et al. Among authors: airola mv. PLoS One. 2022 Sep 1;17(9):e0271540. doi: 10.1371/journal.pone.0271540. eCollection 2022. PLoS One. 2022. PMID: 36048828 Free PMC article.

2

Sphingolipid metabolism and neutral sphingomyelinases.

Airola MV, Hannun YA. Airola MV, et al. Handb Exp Pharmacol. 2013;(215):57-76. doi: 10.1007/978-3-7091-1368-4_3. Handb Exp Pharmacol. 2013. PMID: 23579449 Free PMC article. Review.

3

Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide.

Airola MV, Tumolo JM, Snider J, Hannun YA. Airola MV, et al. PLoS One. 2014 Aug 21;9(8):e105830. doi: 10.1371/journal.pone.0105830. eCollection 2014. PLoS One. 2014. PMID: 25144372 Free PMC article.

4

Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes.

Shamseddine AA, Airola MV, Hannun YA. Shamseddine AA, et al. Among authors: airola mv. Adv Biol Regul. 2015 Jan;57:24-41. doi: 10.1016/j.jbior.2014.10.002. Epub 2014 Oct 27. Adv Biol Regul. 2015. PMID: 25465297 Free PMC article. Review.

5

Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.

Airola MV, Allen WJ, Pulkoski-Gross MJ, Obeid LM, Rizzo RC, Hannun YA. Airola MV, et al. Structure. 2015 Aug 4;23(8):1482-1491. doi: 10.1016/j.str.2015.06.013. Epub 2015 Jul 16. Structure. 2015. PMID: 26190575 Free PMC article.

6

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.

Shamseddine AA, Clarke CJ, Carroll B, Airola MV, Mohammed S, Rella A, Obeid LM, Hannun YA. Shamseddine AA, et al. Among authors: airola mv. Cell Death Dis. 2015 Oct 29;6(10):e1947. doi: 10.1038/cddis.2015.268. Cell Death Dis. 2015. PMID: 26512957 Free PMC article.

7

Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation.

Airola MV, Shanbhogue P, Shamseddine AA, Guja KE, Senkal CE, Maini R, Bartke N, Wu BX, Obeid LM, Garcia-Diaz M, Hannun YA. Airola MV, et al. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5549-E5558. doi: 10.1073/pnas.1705134114. Epub 2017 Jun 26. Proc Natl Acad Sci U S A. 2017. PMID: 28652336 Free PMC article.

8

Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae.

Ren J, Snider J, Airola MV, Zhong A, Rana NA, Obeid LM, Hannun YA. Ren J, et al. Among authors: airola mv. J Lipid Res. 2018 Jan;59(1):162-170. doi: 10.1194/jlr.D078535. Epub 2017 Nov 1. J Lipid Res. 2018. PMID: 29092960 Free PMC article.

9

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme.

Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA. Shanbhogue P, et al. Among authors: airola mv. J Biol Chem. 2019 May 3;294(18):7488-7502. doi: 10.1074/jbc.RA118.007288. Epub 2019 Mar 19. J Biol Chem. 2019. PMID: 30890560 Free PMC article.

10

Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening.

Otsuka Y, Airola MV, Choi YM, Coant N, Snider J, Cariello C, Saied EM, Arenz C, Bannister T, Rahaim R Jr, Hannun YA, Shumate J, Scampavia L, Haley JD, Spicer TP. Otsuka Y, et al. Among authors: airola mv. SLAS Discov. 2021 Jan;26(1):113-121. doi: 10.1177/2472555220945283. Epub 2020 Jul 31. SLAS Discov. 2021. PMID: 32734807 Free PMC article.

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