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Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity.
Güner G, Aßfalg M, Zhao K, Dreyer T, Lahiri S, Lo Y, Slivinschi BI, Imhof A, Jocher G, Strohm L, Behrends C, Langosch D, Bronger H, Nimsky C, Bartsch JW, Riddell SR, Steiner H, Lichtenthaler SF. Güner G, et al. Among authors: assfalg m. EMBO Mol Med. 2022 Oct 10;14(10):e16084. doi: 10.15252/emmm.202216084. Epub 2022 Sep 7. EMBO Mol Med. 2022. PMID: 36069059 Free PMC article.
The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
Schmidt A, Hrupka B, van Bebber F, Sunil Kumar S, Feng X, Tschirner SK, Aßfalg M, Müller SA, Hilger LS, Hofmann LI, Pigoni M, Jocher G, Voytyuk I, Self EL, Ito M, Hyakkoku K, Yoshimura A, Horiguchi N, Feederle R, De Strooper B, Schulte-Merker S, Lammert E, Moechars D, Schmid B, Lichtenthaler SF. Schmidt A, et al. Among authors: assfalg m. J Clin Invest. 2024 Jun 18;134(16):e170550. doi: 10.1172/JCI170550. J Clin Invest. 2024. PMID: 38888964 Free PMC article.
Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2.
Grifagni D, Lenci E, De Santis A, Orsetti A, Barracchia CG, Tedesco F, Bellini Puglielli R, Lucarelli F, Lauriola A, Assfalg M, Cantini F, Calderone V, Guardavaccaro D, Trabocchi A, D'Onofrio M, Ciofi-Baffoni S. Grifagni D, et al. Among authors: assfalg m. ACS Med Chem Lett. 2024 Jan 10;15(2):250-257. doi: 10.1021/acsmedchemlett.3c00498. eCollection 2024 Feb 8. ACS Med Chem Lett. 2024. PMID: 38352832
Site-Specific Ubiquitination of Tau Amyloids Promoted by the E3 Ligase CHIP.
Parolini F, Ataie Kachoie E, Leo G, Civiero L, Bubacco L, Arrigoni G, Munari F, Assfalg M, D'Onofrio M, Capaldi S. Parolini F, et al. Among authors: assfalg m. Angew Chem Int Ed Engl. 2023 Dec 11;62(50):e202310230. doi: 10.1002/anie.202310230. Epub 2023 Nov 10. Angew Chem Int Ed Engl. 2023. PMID: 37878393
93 results