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Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling.
Mishra S, Cosentino C, Tamta AK, Khan D, Srinivasan S, Ravi V, Abbotto E, Arathi BP, Kumar S, Jain A, Ramaian AS, Kizkekra SM, Rajagopal R, Rao S, Krishna S, Asirvatham-Jeyaraj N, Haggerty ER, Silberman DM, Kurland IJ, Veeranna RP, Jayavelu T, Bruzzone S, Mostoslavsky R, Sundaresan NR. Mishra S, et al. Among authors: tamta ak. Nat Commun. 2022 Sep 15;13(1):5415. doi: 10.1038/s41467-022-32905-w. Nat Commun. 2022. PMID: 36109503 Free PMC article.
SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis.
Sarikhani M, Maity S, Mishra S, Jain A, Tamta AK, Ravi V, Kondapalli MS, Desingu PA, Khan D, Kumar S, Rao S, Inbaraj M, Pandit AS, Sundaresan NR. Sarikhani M, et al. Among authors: tamta ak. J Biol Chem. 2018 Apr 6;293(14):5281-5294. doi: 10.1074/jbc.RA117.000915. Epub 2018 Feb 13. J Biol Chem. 2018. PMID: 29440391 Free PMC article.
Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice.
Spurthi KM, Sarikhani M, Mishra S, Desingu PA, Yadav S, Rao S, Maity S, Tamta AK, Kumar S, Majumdar S, Jain A, Raghuraman A, Khan D, Singh I, Samuel RJ, Ramachandra SG, Nandi D, Sundaresan NR. Spurthi KM, et al. Among authors: tamta ak. J Biol Chem. 2018 Aug 24;293(34):13073-13089. doi: 10.1074/jbc.RA118.001880. Epub 2018 Jun 21. J Biol Chem. 2018. PMID: 29929978 Free PMC article.
SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ.
Khan D, Ara T, Ravi V, Rajagopal R, Tandon H, Parvathy J, Gonzalez EA, Asirvatham-Jeyaraj N, Krishna S, Mishra S, Raghu S, Bhati AS, Tamta AK, Dasgupta S, Kolthur-Seetharam U, Etchegaray JP, Mostoslavsky R, Rao PSM, Srinivasan N, Sundaresan NR. Khan D, et al. Among authors: tamta ak. Cell Rep. 2021 Jun 1;35(9):109190. doi: 10.1016/j.celrep.2021.109190. Cell Rep. 2021. PMID: 34077730 Free PMC article.
PARP1 inhibition protects mice against Japanese encephalitis virus infection.
Desingu PA, Mishra S, Dindi L, Srinivasan S, Rajmani RS, Ravi V, Tamta AK, Raghu S, Murugasamy K, Pandit AS, Sundaresan NR. Desingu PA, et al. Among authors: tamta ak. Cell Rep. 2023 Sep 26;42(9):113103. doi: 10.1016/j.celrep.2023.113103. Epub 2023 Sep 6. Cell Rep. 2023. PMID: 37676769 Free article.