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Selected commensals educate the intestinal vascular and immune system for immunocompetence.
Romero R, Zarzycka A, Preussner M, Fischer F, Hain T, Herrmann JP, Roth K, Keber CU, Suryamohan K, Raifer H, Luu M, Leister H, Bertrams W, Klein M, Shams-Eldin H, Jacob R, Mollenkopf HJ, Rajalingam K, Visekruna A, Steinhoff U. Romero R, et al. Among authors: klein m. Microbiome. 2022 Sep 28;10(1):158. doi: 10.1186/s40168-022-01353-5. Microbiome. 2022. PMID: 36171625 Free PMC article.
Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells.
Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U. Visekruna A, et al. Among authors: klein m. J Clin Invest. 2019 Apr 2;129(5):1972-1983. doi: 10.1172/JCI98929. eCollection 2019 Apr 2. J Clin Invest. 2019. PMID: 30939122 Free PMC article.
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.
Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M. Lückel C, et al. Among authors: klein m. Nat Commun. 2019 Dec 16;10(1):5722. doi: 10.1038/s41467-019-13731-z. Nat Commun. 2019. PMID: 31844089 Free PMC article.
Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.
Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A, Klein M, Wempe A, Leister H, Raifer H, Picard F, Muhammad K, Ohl K, Romero R, Fischer F, Bauer CA, Huber M, Gress TM, Lauth M, Danhof S, Bopp T, Nerreter T, Mulder IE, Steinhoff U, Hudecek M, Visekruna A. Luu M, et al. Among authors: klein m. Nat Commun. 2021 Jul 1;12(1):4077. doi: 10.1038/s41467-021-24331-1. Nat Commun. 2021. PMID: 34210970 Free PMC article.
ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers.
Mooz J, Riegel K, Ps H, Sadanandam A, Marini F, Klein M, Werner U, Roth W, Wilken-Schmitz A, Tegeder I, Rajalingam K. Mooz J, et al. Among authors: klein m. Sci Adv. 2022 Mar 18;8(11):eabk1538. doi: 10.1126/sciadv.abk1538. Epub 2022 Mar 18. Sci Adv. 2022. PMID: 35302851 Free PMC article.
IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.
Das Gupta D, Paul C, Samel N, Bieringer M, Staudenraus D, Marini F, Raifer H, Menke L, Hansal L, Camara B, Roth E, Daum P, Wanzel M, Mernberger M, Nist A, Bauer UM, Helmprobst F, Buchholz M, Roth K, Bastian L, Hartmann AM, Baldus C, Ikuta K, Neubauer A, Burchert A, Jäck HM, Klein M, Bopp T, Stiewe T, Pagenstecher A, Lohoff M. Das Gupta D, et al. Among authors: klein m. Cell Death Differ. 2022 Nov;29(11):2163-2176. doi: 10.1038/s41418-022-01005-z. Epub 2022 Apr 22. Cell Death Differ. 2022. PMID: 35459909 Free PMC article.
The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.
Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker HW, Huber M. Raczkowski F, et al. Among authors: klein m. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15019-24. doi: 10.1073/pnas.1309378110. Epub 2013 Aug 26. Proc Natl Acad Sci U S A. 2013. PMID: 23980171 Free PMC article.
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4.
Campos Carrascosa L, Klein M, Kitagawa Y, Lückel C, Marini F, König A, Guralnik A, Raifer H, Hagner-Benes S, Rädler D, Böck A, Kang C, Lohoff M, Garn H, Schaub B, Berberich-Siebelt F, Sakaguchi S, Bopp T, Huber M. Campos Carrascosa L, et al. Among authors: klein m. Nat Commun. 2017 May 12;8:15366. doi: 10.1038/ncomms15366. Nat Commun. 2017. PMID: 28497800 Free PMC article.
ERK3/MAPK6 controls IL-8 production and chemotaxis.
Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, Klein M, Michel C, Radsak MP, Rosigkeit S, Grimminger P, Schild H, Rajalingam K. Bogucka K, et al. Among authors: klein m. Elife. 2020 Apr 21;9:e52511. doi: 10.7554/eLife.52511. Elife. 2020. PMID: 32314963 Free PMC article.
Modulation of cellular transcriptome and proteome composition by azidohomoalanine-implications on click chemistry-based secretome analysis.
Kirschner F, Arnold-Schild D, Leps C, Łącki MK, Klein M, Chen Y, Ludt A, Marini F, Kücük C, Stein L, Distler U, Sielaff M, Michna T, Riegel K, Rajalingam K, Bopp T, Tenzer S, Schild H. Kirschner F, et al. Among authors: klein m. J Mol Med (Berl). 2023 Jul;101(7):855-867. doi: 10.1007/s00109-023-02333-4. Epub 2023 May 26. J Mol Med (Berl). 2023. PMID: 37231147 Free PMC article.
6,663 results