Yan G - Search Results

1

Discovery of 2-Methyl-2-(4-(2-methyl-8-(1H-pyrrolo[2,3-b]pyridin-6-yl)-1H-naphtho[1,2-d]imidazol-1-yl)phenyl)propanenitrile as a Novel PI3K/mTOR Inhibitor with Enhanced Antitumor Efficacy In Vitro and In Vivo.

Yang J, Liu Y, Lan S, Yu S, Ma X, Luo D, Shan H, Zhong X, Yan G, Li R. Yang J, et al. Among authors: yan g. J Med Chem. 2022 Oct 13;65(19):12781-12801. doi: 10.1021/acs.jmedchem.2c00572. Epub 2022 Oct 3. J Med Chem. 2022. PMID: 36191148

2

Analysis of furo[3,2-c]tetrahydroquinoline and pyrano[3,2-c]tetrahydroquinoline derivatives as antitumor agents and their metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry.

Hou X, Luo H, Zhong H, Wu F, Zhou M, Zhang W, Han X, Yan G, Zhang M, Lu L, Ding Z, He G, Li R. Hou X, et al. Among authors: yan g. Rapid Commun Mass Spectrom. 2013 Jun 15;27(11):1222-30. doi: 10.1002/rcm.6562. Rapid Commun Mass Spectrom. 2013. PMID: 23650035

3

Synthesis and biological evaluation of 4-(1,2,3-triazol-1-yl)coumarin derivatives as potential antitumor agents.

Zhang W, Li Z, Zhou M, Wu F, Hou X, Luo H, Liu H, Han X, Yan G, Ding Z, Li R. Zhang W, et al. Among authors: yan g. Bioorg Med Chem Lett. 2014 Feb 1;24(3):799-807. doi: 10.1016/j.bmcl.2013.12.095. Epub 2013 Dec 29. Bioorg Med Chem Lett. 2014. PMID: 24418772

4

Synthesis and biological evaluation of novel 2,3-dihydrochromeno[3,4-d]imidazol-4(1H)-one derivatives as potent anticancer cell proliferation and migration agents.

Han X, Luo J, Wu F, Hou X, Yan G, Zhou M, Zhang M, Pu C, Li R. Han X, et al. Among authors: yan g. Eur J Med Chem. 2016 May 23;114:232-43. doi: 10.1016/j.ejmech.2016.01.035. Epub 2016 Feb 5. Eur J Med Chem. 2016. PMID: 26994691

5

Synthesis, biological evaluation and molecular docking study of N-(2-methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif antagonists.

Zhou M, Luo RH, Hou XY, Wang RR, Yan GY, Chen H, Zhang RH, Shi JY, Zheng YT, Li R, Wei YQ. Zhou M, et al. Eur J Med Chem. 2017 Mar 31;129:310-324. doi: 10.1016/j.ejmech.2017.01.010. Epub 2017 Jan 12. Eur J Med Chem. 2017. PMID: 28235704

6

Design, Synthesis, and Biological Evaluation of Dimorpholine Substituted Thienopyrimidines as Potential Class I PI3K/mTOR Dual Inhibitors.

Zhan M, Deng Y, Zhao L, Yan G, Wang F, Tian Y, Zhang L, Jiang H, Chen Y. Zhan M, et al. Among authors: yan g. J Med Chem. 2017 May 11;60(9):4023-4035. doi: 10.1021/acs.jmedchem.7b00357. Epub 2017 Apr 24. J Med Chem. 2017. PMID: 28409639

7

Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors.

Pu C, Luo RH, Zhang M, Hou X, Yan G, Luo J, Zheng YT, Li R. Pu C, et al. Among authors: yan g. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4150-4155. doi: 10.1016/j.bmcl.2017.07.026. Epub 2017 Jul 10. Bioorg Med Chem Lett. 2017. PMID: 28754362

8

Pharmacophore-based virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation for the discovery of novel BRD4 inhibitors.

Yan G, Hou M, Luo J, Pu C, Hou X, Lan S, Li R. Yan G, et al. Chem Biol Drug Des. 2018 Feb;91(2):478-490. doi: 10.1111/cbdd.13109. Epub 2017 Oct 9. Chem Biol Drug Des. 2018. PMID: 28901664

9

Assessing the performance of docking scoring function, FEP, MM-GBSA, and QM/MM-GBSA approaches on a series of PLK1 inhibitors.

Pu C, Yan G, Shi J, Li R. Pu C, et al. Among authors: yan g. Medchemcomm. 2017 May 22;8(7):1452-1458. doi: 10.1039/c7md00184c. eCollection 2017 Jul 1. Medchemcomm. 2017. PMID: 30108856 Free PMC article.

10

Synthesis and biological evaluation of 3-(1,3,4-oxadiazol-2-yl)-1,8-naphthyridin-4(1H)-ones as cisplatin sensitizers.

Hou X, Luo H, Zhang M, Yan G, Pu C, Lan S, Li R. Hou X, et al. Among authors: yan g. Medchemcomm. 2018 Sep 25;9(11):1949-1960. doi: 10.1039/c8md00464a. eCollection 2018 Nov 1. Medchemcomm. 2018. PMID: 30568762 Free PMC article.

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