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Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data.
Gaohua L, Neuhoff S, Johnson TN, Rostami-Hodjegan A, Jamei M. Gaohua L, et al. Drug Metab Pharmacokinet. 2016 Jun;31(3):224-33. doi: 10.1016/j.dmpk.2016.03.005. Epub 2016 Apr 4. Drug Metab Pharmacokinet. 2016. PMID: 27236639 Free article.
The Interplay of Permeability, Metabolism, Transporters, and Dosing in Determining the Dynamics of the Tissue/Plasma Partition Coefficient and Volume of Distribution-A Theoretical Investigation Using Permeability-Limited, Physiologically Based Pharmacokinetic Modeling.
Gaohua L, Zhang M, Sychterz C, Chang M, Schmidt BJ. Gaohua L, et al. Int J Mol Sci. 2023 Nov 12;24(22):16224. doi: 10.3390/ijms242216224. Int J Mol Sci. 2023. PMID: 38003416 Free PMC article.
21 results