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CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.
Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. Leng K, et al. Among authors: schrag ms. Nat Neurosci. 2022 Nov;25(11):1528-1542. doi: 10.1038/s41593-022-01180-9. Epub 2022 Oct 27. Nat Neurosci. 2022. PMID: 36303069 Free PMC article.
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin.
Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kampmann M, Lippmann ES. Kim H, et al. Among authors: schrag ms. Nat Commun. 2022 Nov 2;13(1):6581. doi: 10.1038/s41467-022-34412-4. Nat Commun. 2022. PMID: 36323693 Free PMC article.
Detection, Visualization and Quantification of Protein Complexes in Human Alzheimer's Disease Brains using Proximity Ligation Assay.
Romero-Fernandez W, Carvajal-Tapia C, Prusky A, Katdare K, Wang E, Shostak A, Ventura-Antunes L, Harmsen H, Lippmann E, Borroto-Escuela D, MacGurn J, Fuxe K, Schrag M. Romero-Fernandez W, et al. Res Sq [Preprint]. 2023 Feb 16:rs.3.rs-2570335. doi: 10.21203/rs.3.rs-2570335/v1. Res Sq. 2023. Update in: Sci Rep. 2023 Jul 24;13(1):11948. doi: 10.1038/s41598-023-38000-4. PMID: 36824944 Free PMC article. Updated. Preprint.
Detection, visualization and quantification of protein complexes in human Alzheimer's disease brains using proximity ligation assay.
Romero-Fernandez W, Carvajal-Tapia C, Prusky A, Katdare KA, Wang E, Shostak A, Ventura-Antunes L, Harmsen HJ, Lippmann ES, Fuxe K, MacGurn JA, Borroto-Escuela DO, Schrag MS. Romero-Fernandez W, et al. Among authors: schrag ms. Sci Rep. 2023 Jul 24;13(1):11948. doi: 10.1038/s41598-023-38000-4. Sci Rep. 2023. PMID: 37488165 Free PMC article.
Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.
Sorets AG, Schwensen KR, Francini N, Kjar A, Abdulrahman AM, Shostak A, Katdare KA, Schoch KM, Cowell RP, Park JC, Ligocki AP, Ford WT, Ventura-Antunes L, Hoogenboezem EN, Prusky A, Castleberry M, Michell DL, Miller TM, Vickers KC, Schrag MS, Duvall CL, Lippmann ES. Sorets AG, et al. Among authors: schrag ms. bioRxiv [Preprint]. 2024 Sep 7:2024.06.09.598079. doi: 10.1101/2024.06.09.598079. bioRxiv. 2024. PMID: 38915549 Free PMC article. Preprint.
15 results