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Engineered Mycobacteriophage TM4::GeNL Rapidly Determines Bedaquiline, Pretomanid, Linezolid, Rifampicin, and Clofazimine Sensitivity in Mycobacterium tuberculosis Clinical Isolates.
Rajagopalan S, Rourke AK, Asare E, Kohlerschmidt DJ, Das L, Ngema SL, Mulholland CV, Vilchèze C, Mahalingam V, Moodley S, Truebody B, Mackenzie J, Steyn AJC, Perumal R, Berney M, Larsen MH, O'Donnell MR, Escuyer VE, Jacobs WR Jr. Rajagopalan S, et al. Among authors: truebody b. J Infect Dis. 2024 Oct 16:jiae438. doi: 10.1093/infdis/jiae438. Online ahead of print. J Infect Dis. 2024. PMID: 39412357
Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10.
Ahmed M, Mackenzie J, Tezera L, Krause R, Truebody B, Garay-Baquero D, Vallejo A, Govender K, Adamson J, Fisher H, Essex JW, Mansour S, Elkington P, Steyn AJC, Leslie A. Ahmed M, et al. Among authors: truebody b. Commun Biol. 2022 Dec 1;5(1):1317. doi: 10.1038/s42003-022-04265-0. Commun Biol. 2022. PMID: 36456824 Free PMC article.
Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis.
Saini V, Chinta KC, Reddy VP, Glasgow JN, Stein A, Lamprecht DA, Rahman MA, Mackenzie JS, Truebody BE, Adamson JH, Kunota TTR, Bailey SM, Moellering DR, Lancaster JR Jr, Steyn AJC. Saini V, et al. Among authors: truebody be. Nat Commun. 2020 Jan 28;11(1):557. doi: 10.1038/s41467-019-14132-y. Nat Commun. 2020. PMID: 31992699 Free PMC article.