Keith KA - Search Results

1

NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin.

Lipka E, Chadderdon AM, Harteg CC, Doherty MK, Simon ES, Domagala JM, Reyna DM, Hutchings KM, Gan X, White AD, Hartline CB, Harden EA, Keith KA, Prichard MN, James SH, Cardin RD, Bernstein DI, Spencer JF, Tollefson AE, Wold WSM, Toth K. Lipka E, et al. Among authors: keith ka. Mol Pharm. 2023 Jan 2;20(1):370-382. doi: 10.1021/acs.molpharmaceut.2c00668. Epub 2022 Dec 9. Mol Pharm. 2023. PMID: 36484496 Free PMC article.

2

Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.

Kern ER, Hartline C, Harden E, Keith K, Rodriguez N, Beadle JR, Hostetler KY. Kern ER, et al. Antimicrob Agents Chemother. 2002 Apr;46(4):991-5. doi: 10.1128/AAC.46.4.991-995.2002. Antimicrob Agents Chemother. 2002. PMID: 11897580 Free PMC article.

3

The 4',4'-difluoro analog of 5'-noraristeromycin: a new structural prototype for possible antiviral drug development toward orthopoxvirus and cytomegalovirus.

Roy A, Schneller SW, Keith KA, Hartline CB, Kern ER. Roy A, et al. Among authors: keith ka. Bioorg Med Chem. 2005 Jul 15;13(14):4443-9. doi: 10.1016/j.bmc.2005.04.044. Bioorg Med Chem. 2005. PMID: 15908221

4

Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs.

Prichard MN, Williams AD, Keith KA, Harden EA, Kern ER. Prichard MN, et al. Among authors: keith ka. Antiviral Res. 2006 Aug;71(1):1-6. doi: 10.1016/j.antiviral.2006.01.013. Epub 2006 Feb 28. Antiviral Res. 2006. PMID: 16530858

5

Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.

Prichard MN, Keith KA, Quenelle DC, Kern ER. Prichard MN, et al. Among authors: keith ka. Antimicrob Agents Chemother. 2006 Apr;50(4):1336-41. doi: 10.1128/AAC.50.4.1336-1341.2006. Antimicrob Agents Chemother. 2006. PMID: 16569849 Free PMC article.

6

Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.

Choo H, Beadle JR, Kern ER, Prichard MN, Keith KA, Hartline CB, Trahan J, Aldern KA, Korba BE, Hostetler KY. Choo H, et al. Among authors: keith ka. Antimicrob Agents Chemother. 2007 Feb;51(2):611-5. doi: 10.1128/AAC.00444-06. Epub 2006 Nov 27. Antimicrob Agents Chemother. 2007. PMID: 17130297 Free PMC article.

7

Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.

Prichard MN, Keith KA, Johnson MP, Harden EA, McBrayer A, Luo M, Qiu S, Chattopadhyay D, Fan X, Torrence PF, Kern ER. Prichard MN, et al. Among authors: keith ka. Antimicrob Agents Chemother. 2007 May;51(5):1795-803. doi: 10.1128/AAC.01447-06. Epub 2007 Feb 26. Antimicrob Agents Chemother. 2007. PMID: 17325220 Free PMC article.

8

Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.

Ruiz JC, Beadle JR, Aldern KA, Keith KA, Hartline CB, Kern ER, Hostetler KY. Ruiz JC, et al. Among authors: keith ka. Antiviral Res. 2007 Jul;75(1):87-90. doi: 10.1016/j.antiviral.2006.09.005. Epub 2006 Oct 10. Antiviral Res. 2007. PMID: 17367874 Free PMC article.

9

Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses.

Quenelle DC, Prichard MN, Keith KA, Hruby DE, Jordan R, Painter GR, Robertson A, Kern ER. Quenelle DC, et al. Among authors: keith ka. Antimicrob Agents Chemother. 2007 Nov;51(11):4118-24. doi: 10.1128/AAC.00762-07. Epub 2007 Aug 27. Antimicrob Agents Chemother. 2007. PMID: 17724153 Free PMC article.

10

Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine.

Prichard MN, Kern ER, Quenelle DC, Keith KA, Moyer RW, Turner PC. Prichard MN, et al. Among authors: keith ka. Virol J. 2008 Mar 5;5:39. doi: 10.1186/1743-422X-5-39. Virol J. 2008. PMID: 18321387 Free PMC article.

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