O'Neill PM - Search Results

1

Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis.

Jeffreys LN, Ardrey A, Hafiz TA, Dyer LA, Warman AJ, Mosallam N, Nixon GL, Fisher NE, Hong WD, Leung SC, Aljayyoussi G, Bibby J, Almeida DV, Converse PJ, Fotouhi N, Berry NG, Nuermberger EL, Upton AM, O'Neill PM, Ward SA, Biagini GA. Jeffreys LN, et al. ACS Infect Dis. 2023 Feb 10;9(2):221-238. doi: 10.1021/acsinfecdis.2c00283. Epub 2023 Jan 6. ACS Infect Dis. 2023. PMID: 36606559 Free PMC article.

2

The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse.

Ruscoe JE, Jewell H, Maggs JL, O'Neill PM, Storr RC, Ward SA, Park BK. Ruscoe JE, et al. J Pharmacol Exp Ther. 1995 Apr;273(1):393-404. J Pharmacol Exp Ther. 1995. PMID: 7714794

3

The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.

O'Neill PM, Harrison AC, Storr RC, Hawley SR, Ward SA, Park BK. O'Neill PM, et al. J Med Chem. 1994 Apr 29;37(9):1362-70. doi: 10.1021/jm00035a017. J Med Chem. 1994. PMID: 8176713

4

The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.

Hawley SR, Bray PG, O'Neill PM, Park BK, Ward SA. Hawley SR, et al. Biochem Pharmacol. 1996 Sep 13;52(5):723-33. doi: 10.1016/0006-2952(96)00354-1. Biochem Pharmacol. 1996. PMID: 8765470

5

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component.

Hawley SR, Bray PG, O'Neill PM, Naisbitt DJ, Park BK, Ward SA. Hawley SR, et al. Antimicrob Agents Chemother. 1996 Oct;40(10):2345-9. doi: 10.1128/AAC.40.10.2345. Antimicrob Agents Chemother. 1996. PMID: 8891142 Free PMC article.

6

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin.

O'Neill PM, Bishop LP, Storr RC, Hawley SR, Maggs JL, Ward SA, Park BK. O'Neill PM, et al. J Med Chem. 1996 Oct 25;39(22):4511-4. doi: 10.1021/jm9604944. J Med Chem. 1996. PMID: 8893847

7

Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.

O'Neill PM, Willock DJ, Hawley SR, Bray PG, Storr RC, Ward SA, Park BK. O'Neill PM, et al. J Med Chem. 1997 Feb 14;40(4):437-48. doi: 10.1021/jm960370r. J Med Chem. 1997. PMID: 9046333

8

4-Aminoquinolines--past, present, and future: a chemical perspective.

O'Neill PM, Bray PG, Hawley SR, Ward SA, Park BK. O'Neill PM, et al. Pharmacol Ther. 1998 Jan;77(1):29-58. doi: 10.1016/s0163-7258(97)00084-3. Pharmacol Ther. 1998. PMID: 9500158 Review.

9

Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro.

Hawley SR, Bray PG, Mungthin M, Atkinson JD, O'Neill PM, Ward SA. Hawley SR, et al. Antimicrob Agents Chemother. 1998 Mar;42(3):682-6. doi: 10.1128/AAC.42.3.682. Antimicrob Agents Chemother. 1998. PMID: 9517951 Free PMC article.

10

New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain.

Raynes KJ, Stocks PA, O'Neill PM, Park BK, Ward SA. Raynes KJ, et al. J Med Chem. 1999 Jul 29;42(15):2747-51. doi: 10.1021/jm9901374. J Med Chem. 1999. PMID: 10425085

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